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Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats
dc.contributor.author | Herrera, Maria I. | |
dc.contributor.author | Udovin, Lucas D. | |
dc.contributor.author | Kobiec, Tamara | |
dc.contributor.author | Toro-Urrego, Nicolas | |
dc.contributor.author | Kusnier, Carlos F. | |
dc.contributor.author | Kölliker-Frers, Rodolfo A. | |
dc.contributor.author | Luaces, Juan P. | |
dc.contributor.author | Otero-Losada, Matilde | |
dc.contributor.author | Capani, Francisco | |
dc.date.accessioned | 2024-04-10T05:54:15Z | |
dc.date.available | 2024-04-10T05:54:15Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.3389/fnbeh.2022.953157 | |
dc.identifier.issn | 16625153 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/10848 | |
dc.description.abstract | Impaired gas exchange close to labor causes perinatal asphyxia (PA), a neurodevelopmental impairment factor. Palmitoylethanolamide (PEA) proved neuroprotective in experimental brain injury and neurodegeneration models. This study aimed to evaluate PEA effects on the immature-brain, i.e., early neuroprotection by PEA in an experimental PA paradigm. Newborn rats were placed in a 37°C water bath for 19 min to induce PA. PEA 10 mg/kg, s.c., was administered within the first hour of life. Neurobehavioral responses were assessed from postnatal day 1 (P1) to postnatal day 21 (P21), recording the day of appearance of several reflexes and neurological signs. Hippocampal CA1 area ultrastructure was examined using electron microscopy. Microtubule-associated protein 2 (MAP-2), phosphorylated high and medium molecular weight neurofilaments (pNF H/M), and glial fibrillary acidic protein (GFAP) were assessed using immunohistochemistry and Western blot at P21. Over the first 3 weeks of life, PA rats showed late gait, negative geotaxis and eye-opening onset, and delayed appearance of air-righting, auditory startle, sensory eyelid, forelimb placing, and grasp reflexes. On P21, the hippocampal CA1 area showed signs of neuronal degeneration and MAP-2 deficit. PEA treatment reduced PA-induced hippocampal damage and normalized the time of appearance of gait, air-righting, placing, and grasp reflexes. The outcome of this study might prove useful in designing intervention strategies to reduce early neurodevelopmental delay following PA. Copyright © 2022 Herrera, Udovin, Kobiec, Toro-Urrego, Kusnier, Kölliker-Frers, Luaces, Otero-Losada and Capani. | es_ES |
dc.description.sponsorship | Consejo Nacional de Investigaciones Científicas y Técnicas, CONICET | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Frontiers Media S.A. | es_ES |
dc.subject | hippocampal CA1 area | es_ES |
dc.subject | neurodevelopmental disorder (NDD) | es_ES |
dc.subject | neuroprotection | es_ES |
dc.subject | palmitoylethanolamide | es_ES |
dc.subject | PEA | es_ES |
dc.subject | perinatal asphyxia | es_ES |
dc.subject | reflexes | es_ES |
dc.title | Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats | es_ES |
dc.type | Article | es_ES |