Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats
Autor
Herrera, Maria I.
Udovin, Lucas D.
Kobiec, Tamara
Toro-Urrego, Nicolas
Kusnier, Carlos F.
Kölliker-Frers, Rodolfo A.
Luaces, Juan P.
Otero-Losada, Matilde
Capani, Francisco
Resumen
Impaired gas exchange close to labor causes perinatal asphyxia (PA), a neurodevelopmental impairment factor. Palmitoylethanolamide (PEA) proved neuroprotective in experimental brain injury and neurodegeneration models. This study aimed to evaluate PEA effects on the immature-brain, i.e., early neuroprotection by PEA in an experimental PA paradigm. Newborn rats were placed in a 37°C water bath for 19 min to induce PA. PEA 10 mg/kg, s.c., was administered within the first hour of life. Neurobehavioral responses were assessed from postnatal day 1 (P1) to postnatal day 21 (P21), recording the day of appearance of several reflexes and neurological signs. Hippocampal CA1 area ultrastructure was examined using electron microscopy. Microtubule-associated protein 2 (MAP-2), phosphorylated high and medium molecular weight neurofilaments (pNF H/M), and glial fibrillary acidic protein (GFAP) were assessed using immunohistochemistry and Western blot at P21. Over the first 3 weeks of life, PA rats showed late gait, negative geotaxis and eye-opening onset, and delayed appearance of air-righting, auditory startle, sensory eyelid, forelimb placing, and grasp reflexes. On P21, the hippocampal CA1 area showed signs of neuronal degeneration and MAP-2 deficit. PEA treatment reduced PA-induced hippocampal damage and normalized the time of appearance of gait, air-righting, placing, and grasp reflexes. The outcome of this study might prove useful in designing intervention strategies to reduce early neurodevelopmental delay following PA. Copyright © 2022 Herrera, Udovin, Kobiec, Toro-Urrego, Kusnier, Kölliker-Frers, Luaces, Otero-Losada and Capani.
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Corrigendum: Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats (Front. Behav. Neurosci., (2022), 16, 953157, 10.3389/fnbeh.2022.953157) (2024)
Herrera, Maria I.; Udovin, Lucas D.; Kobiec, Tamara; Toro-Urrego, Nicolas; Kusnier, Carlos F.; Kölliker-Frers, Rodolfo A.; Luaces, Juan P.; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2022)In the original article, there was an error in affiliations #3 and #4. Instead of “1. Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Pontificia Universidad Católica Argentina, Buenos ... -
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Corrigendum: Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective(Front. Neurosci., (2023), 17, (1214468), 10.3389/fnins.2023.1214468) (2024)
Kobiec, Tamara; Mardaraz, Claudia; Toro-Urrego, Nicolás; Kölliker-Frers, Rodolfo; Capani, Francisco; Otero-Losada, Matilde (Frontiers Media SA, 2023)In the published article, there was an error in original affiliations 3, 4. Affiliations “3Facultad de Psicología y Psicopedagogía, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina, 4Departamento de ... -
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Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective (2024)
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