Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective
Autor
Kobiec, Tamara
Mardaraz, Claudia
Toro-Urrego, Nicolás
Kölliker-Frers, Rodolfo
Capani, Francisco
Otero-Losada, Matilde
Resumen
Metabolic syndrome (MetS) is defined by the concurrence of different metabolic conditions: obesity, hypertension, dyslipidemia, and hyperglycemia. Its incidence has been increasingly rising over the past decades and has become a global health problem. MetS has deleterious consequences on the central nervous system (CNS) and neurological development. MetS can last several years or be lifelong, affecting the CNS in different ways and treatments can help manage condition, though there is no known cure. The early childhood years are extremely important in neurodevelopment, which extends beyond, encompassing a lifetime. Neuroplastic changes take place all life through — childhood, adolescence, adulthood, and old age — are highly sensitive to environmental input. Environmental factors have an important role in the etiopathogenesis and treatment of MetS, so environmental enrichment (EE) stands as a promising non-invasive therapeutic approach. While the EE paradigm has been designed for animal housing, its principles can be and actually are applied in cognitive, sensory, social, and physical stimulation programs for humans. Here, we briefly review the central milestones in neurodevelopment at each life stage, along with the research studies carried out on how MetS affects neurodevelopment at each life stage and the contributions that EE models can provide to improve health over the lifespan. Copyright © 2023 Kobiec, Mardaraz, Toro-Urrego, Kölliker-Frers, Capani and Otero-Losada.
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Corrigendum: Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective(Front. Neurosci., (2023), 17, (1214468), 10.3389/fnins.2023.1214468) (2024)
Kobiec, Tamara; Mardaraz, Claudia; Toro-Urrego, Nicolás; Kölliker-Frers, Rodolfo; Capani, Francisco; Otero-Losada, Matilde (Frontiers Media SA, 2023)In the published article, there was an error in original affiliations 3, 4. Affiliations “3Facultad de Psicología y Psicopedagogía, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina, 4Departamento de ... -
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Corrigendum: Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats (Front. Behav. Neurosci., (2022), 16, 953157, 10.3389/fnbeh.2022.953157) (2024)
Herrera, Maria I.; Udovin, Lucas D.; Kobiec, Tamara; Toro-Urrego, Nicolas; Kusnier, Carlos F.; Kölliker-Frers, Rodolfo A.; Luaces, Juan P.; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2022)In the original article, there was an error in affiliations #3 and #4. Instead of “1. Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Pontificia Universidad Católica Argentina, Buenos ... -
Article
Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats (2024)
Herrera, Maria I.; Udovin, Lucas D.; Kobiec, Tamara; Toro-Urrego, Nicolas; Kusnier, Carlos F.; Kölliker-Frers, Rodolfo A.; Luaces, Juan P.; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2022)Impaired gas exchange close to labor causes perinatal asphyxia (PA), a neurodevelopmental impairment factor. Palmitoylethanolamide (PEA) proved neuroprotective in experimental brain injury and neurodegeneration models. ...