Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy
Autor
Sousa, Alexandre C.C.
Romo, Adolfo I.B.
Almeida, Raimundo R.
Silva, Aiêrta C.C.
Uchoa Dutra Fechine, Lillian Maria
Almeida Brito, Débora Hellen
Melo Freire, Rafael
Pascoalino Pinheiro, Daniel
Ribeiro Da Silva, Larissa Morais
Loiola Pessoa, Otília Deusdênia
Casagrande Denardin, Juliano
Pessoa, Claudia Do Ó.
Silva Ricardo, Nagila Maria Pontes
Resumen
Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
From magneto-dielectric biocomposite films to microstrip antenna devices (2021)
de Menezes, Fernando Lima; Andrade Neto, Davino Machado; Linhares Rodrigues, Maria Do Livramento; Silva Lima, Helder Levi; Paiva, D. V.M.; Santos da Silva, Marcelo Antônio; Uchoa Dutra Fechine, Lillian Maria; Bezerra Sombra, Antônio Sérgio; Melo Freire, Rafael; Casagrande Denardin, Juliano; ... (MDPI AG, 2020)Magneto-dielectric composites are interesting advanced materials principally due to their potential applications in electronic fields, such as in microstrip antennas substrates. In this work, we developed superparamagnetic ... -
Article
Organophosphorus halloysite nanotubes as adsorbent for lead preconcentration in wine and grape juice (2020)
Santana, Allan M.; Melo Freire, Tiago; da Silva, Francisco L.F.; Menezes, Fernando L.; Ramos, Lauren L.; Cavalcante, Giovanna R.; Dutra Fechine, Lillian Maria Uchoa; Sousa Vieira, Laís Helena; Ferreira, Odair P.; Melo Freire, Rafael; ... (Elsevier Ltd, 2020-11-04)Preconcentration of Pb(II) in grape-based beverages using organophosphate-functionalized halloysite nanotubes was investigated by flame atomic absorption spectroscopy (FAAS). For this proposal, a central composition design ... -
Article
A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent (2021)
Andrade Neto, Davino M.; da Costa, Luelc S.; de Menezes, Fernando L.; Fechine, Lillian Maria Uchoa Dutra; Melo Freire, Rafael; Casagrande Denardin, Juliano; Bañobre-López, Manuel; Vasconcelos, Igor F.; Ribeiro, Thiago Soares; Leal, Luzia Kalyne A.M.; ... (Elsevier B.V., 2021-03-30)The great performance of functionalized Fe3O4 nanoparticles (NPs) as contrast agent for magnetic resonance imaging (MRI) is related to the functionalizing agents, once can tune colloidal properties, chemical stability, ...