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Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy
dc.contributor.author | Sousa, Alexandre C.C. | |
dc.contributor.author | Romo, Adolfo I.B. | |
dc.contributor.author | Almeida, Raimundo R. | |
dc.contributor.author | Silva, Aiêrta C.C. | |
dc.contributor.author | Uchoa Dutra Fechine, Lillian Maria | |
dc.contributor.author | Almeida Brito, Débora Hellen | |
dc.contributor.author | Melo Freire, Rafael | |
dc.contributor.author | Pascoalino Pinheiro, Daniel | |
dc.contributor.author | Ribeiro Da Silva, Larissa Morais | |
dc.contributor.author | Loiola Pessoa, Otília Deusdênia | |
dc.contributor.author | Casagrande Denardin, Juliano | |
dc.contributor.author | Pessoa, Claudia Do Ó. | |
dc.contributor.author | Silva Ricardo, Nagila Maria Pontes | |
dc.date.accessioned | 2021-04-22T03:23:43Z | |
dc.date.available | 2021-04-22T03:23:43Z | |
dc.date.issued | 2021-07-15 | |
dc.identifier | 10.1016/j.carbpol.2021.118017 | |
dc.identifier.issn | 01448617 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/8798 | |
dc.description.abstract | Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Elsevier Ltd | es_ES |
dc.subject | Drug delivery vehicles | es_ES |
dc.subject | Magnetic nanocarriers | es_ES |
dc.subject | Nanocapsules | es_ES |
dc.subject | Oncocalyxone A | es_ES |
dc.subject | Prolonged release | es_ES |
dc.subject | SPIONs | es_ES |
dc.title | Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy | es_ES |
dc.type | Article | es_ES |