A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent
Autor
Andrade Neto, Davino M.
da Costa, Luelc S.
de Menezes, Fernando L.
Fechine, Lillian Maria Uchoa Dutra
Melo Freire, Rafael
Casagrande Denardin, Juliano
Bañobre-López, Manuel
Vasconcelos, Igor F.
Ribeiro, Thiago Soares
Leal, Luzia Kalyne A.M.
Costa de Sousa, João Antonio
Gallo, Juan
Almeida Fechine, Pierre Basílio
Resumen
The great performance of functionalized Fe3O4 nanoparticles (NPs) as contrast agent for magnetic resonance imaging (MRI) is related to the functionalizing agents, once can tune colloidal properties, chemical stability, hydrophilicity, overall toxicity, as well as, dipole interparticle interactions. Phosphonate derivatives have proven to be excellent capping agents due to their ability to control the above parameters. However, the available functionalizing agents do not provide enough both attached and free-form phosphoric acid groups on NPs surface. Herein, we report the use of a commercially available amino-phosphonate compound, diethylenetriaminepenta (methylene phosphonic acid, DTPMP), to functionalize Fe3O4 NPs to be potentially applied as MRI contrast agent. For the synthesis of DTPMP-coated Fe3O4 NPs, two methodologies were applied, hydrothermal and sonochemical approaches. Several characterization techniques were performed, confirming the success of surface functionalization, which allowed a deep chemical discussion involving the interactions between DTPMP and Fe3O4 NPs. Furthermore, relaxivity and cytotoxicity analyses confirmed the MRI contrast agent potential of the DTPMP-coated Fe3O4 NPs, presenting non-cytotoxicity profile and high values of transverse relaxivity (357–417 mM−1 s−1). Therefore, this work presents a novel and excellent alternative magnetic material for biological and technological application, mainly considering MRI contrast agent.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
From magneto-dielectric biocomposite films to microstrip antenna devices (2021)
de Menezes, Fernando Lima; Andrade Neto, Davino Machado; Linhares Rodrigues, Maria Do Livramento; Silva Lima, Helder Levi; Paiva, D. V.M.; Santos da Silva, Marcelo Antônio; Uchoa Dutra Fechine, Lillian Maria; Bezerra Sombra, Antônio Sérgio; Melo Freire, Rafael; Casagrande Denardin, Juliano; ... (MDPI AG, 2020)Magneto-dielectric composites are interesting advanced materials principally due to their potential applications in electronic fields, such as in microstrip antennas substrates. In this work, we developed superparamagnetic ... -
Article
Organophosphorus halloysite nanotubes as adsorbent for lead preconcentration in wine and grape juice (2020)
Santana, Allan M.; Melo Freire, Tiago; da Silva, Francisco L.F.; Menezes, Fernando L.; Ramos, Lauren L.; Cavalcante, Giovanna R.; Dutra Fechine, Lillian Maria Uchoa; Sousa Vieira, Laís Helena; Ferreira, Odair P.; Melo Freire, Rafael; ... (Elsevier Ltd, 2020-11-04)Preconcentration of Pb(II) in grape-based beverages using organophosphate-functionalized halloysite nanotubes was investigated by flame atomic absorption spectroscopy (FAAS). For this proposal, a central composition design ... -
Article
Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy (2021)
Sousa, Alexandre C.C.; Romo, Adolfo I.B.; Almeida, Raimundo R.; Silva, Aiêrta C.C.; Uchoa Dutra Fechine, Lillian Maria; Almeida Brito, Débora Hellen; Melo Freire, Rafael; Pascoalino Pinheiro, Daniel; Ribeiro Da Silva, Larissa Morais; Loiola Pessoa, Otília Deusdênia; ... (Elsevier Ltd, 2021-07-15)Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate ...