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A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent
dc.contributor.author | Andrade Neto, Davino M. | |
dc.contributor.author | da Costa, Luelc S. | |
dc.contributor.author | de Menezes, Fernando L. | |
dc.contributor.author | Fechine, Lillian Maria Uchoa Dutra | |
dc.contributor.author | Melo Freire, Rafael | |
dc.contributor.author | Casagrande Denardin, Juliano | |
dc.contributor.author | Bañobre-López, Manuel | |
dc.contributor.author | Vasconcelos, Igor F. | |
dc.contributor.author | Ribeiro, Thiago Soares | |
dc.contributor.author | Leal, Luzia Kalyne A.M. | |
dc.contributor.author | Costa de Sousa, João Antonio | |
dc.contributor.author | Gallo, Juan | |
dc.contributor.author | Almeida Fechine, Pierre Basílio | |
dc.date.accessioned | 2021-01-12T18:18:10Z | |
dc.date.available | 2021-01-12T18:18:10Z | |
dc.date.issued | 2021-03-30 | |
dc.identifier | 10.1016/j.apsusc.2020.148824 | |
dc.identifier.issn | 01694332 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/8131 | |
dc.description.abstract | The great performance of functionalized Fe3O4 nanoparticles (NPs) as contrast agent for magnetic resonance imaging (MRI) is related to the functionalizing agents, once can tune colloidal properties, chemical stability, hydrophilicity, overall toxicity, as well as, dipole interparticle interactions. Phosphonate derivatives have proven to be excellent capping agents due to their ability to control the above parameters. However, the available functionalizing agents do not provide enough both attached and free-form phosphoric acid groups on NPs surface. Herein, we report the use of a commercially available amino-phosphonate compound, diethylenetriaminepenta (methylene phosphonic acid, DTPMP), to functionalize Fe3O4 NPs to be potentially applied as MRI contrast agent. For the synthesis of DTPMP-coated Fe3O4 NPs, two methodologies were applied, hydrothermal and sonochemical approaches. Several characterization techniques were performed, confirming the success of surface functionalization, which allowed a deep chemical discussion involving the interactions between DTPMP and Fe3O4 NPs. Furthermore, relaxivity and cytotoxicity analyses confirmed the MRI contrast agent potential of the DTPMP-coated Fe3O4 NPs, presenting non-cytotoxicity profile and high values of transverse relaxivity (357–417 mM−1 s−1). Therefore, this work presents a novel and excellent alternative magnetic material for biological and technological application, mainly considering MRI contrast agent. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Elsevier B.V. | es_ES |
dc.subject | Amino-phosphonate | es_ES |
dc.subject | Functionalized magnetic nanoparticles | es_ES |
dc.subject | MRI contrast agent | es_ES |
dc.subject | Sonochemistry | es_ES |
dc.title | A novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agent | es_ES |
dc.type | Article | es_ES |