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dc.contributor.authorAguayo, Paula Rivera
dc.contributor.authorLarenas, Tamara Bruna
dc.contributor.authorGodoy, Carlos Alarcón
dc.contributor.authorRivas, Bernardita Cayupe
dc.contributor.authorGonzález-Casanova, Jorge Enrique
dc.contributor.authorRojas-Gómez, Diana Marcela
dc.contributor.authorFuentes, Nelson Caro
dc.date.accessioned2020-11-02T20:32:45Z
dc.date.available2020-11-02T20:32:45Z
dc.date.issued2020-08-28
dc.identifier10.3390/antibiotics9090551
dc.identifier.issn20796382
dc.identifier.urihttps://hdl.handle.net/20.500.12728/7104
dc.description.abstractBovine mastitis (BM) is the most prevalent bacterial infection in the livestock sector, affecting the dairy industry greatly. The prevention and treatment of this disease is mainly made via antibiotics, but the increasing antimicrobial resistance of pathogens has affected the efficiency of conventional drugs. Pseudomonas sp. is one of the pathogens involved in this infection. The therapeutic rate of cure for this environmental mastitis-causing pathogen is practically zero, regardless of treatment. Biofilm formation has been one of the main virulence mechanisms of Pseudomonas hence presenting resistance to antibiotic therapy. We have manufactured chitosan nanoparticles (NQo) with tripolyphosphate (TPP) using ionotropic gelation. These NQo were confronted against a Pseudomonas sp. strain isolated from milk samples of cows diagnosed with BM, to evaluate their antimicrobial and antibiofilm capacity. The NQo showed great antibacterial effect in the minimum inhibitory concentrations (MIC), minimum bactericidal concentration (MBC) and disk diffusion assays. Using sub lethal concentrations, NQo were tested for inhibition of biofilm formation. The results show that the nanoparticles exhibited biofilm inhibition and were capable of eradicate pre-existing mature biofilm. These findings indicate that the NQo could act as a potential alternative to antibiotic treatment of BM.es_ES
dc.language.isoenes_ES
dc.publisherMDPI AGes_ES
dc.subjectAntibiofilmes_ES
dc.subjectBovine mastitises_ES
dc.subjectChitosanes_ES
dc.subjectNanoparticleses_ES
dc.subjectPseudomonases_ES
dc.titleAntimicrobial and antibiofilm capacity of chitosan nanoparticles against wild type strain of pseudomonas sp. Isolated from milk of cows diagnosed with bovine mastitises_ES
dc.typeArticlees_ES


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