New insights on the role of connexins and gap junctions channels in adipose tissue and obesity
Autor
González-Casanova, Jorge Enrique
Durán-Agüero, Samuel
Caro-Fuentes, Nelson Javier
Gamboa-Arancibia, Maria Elena
Bruna, Tamara C.
Bermúdez, Valmore
Rojas Gómez, Diana
Resumen
Due to the inability to curb the excessive increase in the prevalence of obesity and over-weight, it is necessary to comprehend in more detail the factors involved in the pathophysiology and to appreciate more clearly the biochemical and molecular mechanisms of obesity. Thus, understanding the biological regulation of adipose tissue is of fundamental relevance. Connexin, a protein that forms intercellular membrane channels of gap junctions and unopposed hemichannels, plays a key role in adipogenesis and in the maintenance of adipose tissue homeostasis. The expression and function of Connexin 43 (Cx43) during the different stages of the adipogenesis are differentially regulated. Moreover, it has been shown that cell–cell communication decreases dramatically upon differentiation into adipocytes. Furthermore, inhibition of Cx43 degradation or constitutive overexpression of Cx43 blocks adipocyte differentiation. In the first events of adipogenesis, the connexin is highly phosphorylated, which is likely associated with enhanced Gap Junction (GJ) communication. In an intermediate state of adipocyte differentiation, Cx43 phosphorylation decreases, as it is displaced from the membrane and degraded through the proteasome; thus, Cx43 total protein is reduced. Cx is involved in cardiac disease as well as in obesity-related cardiovascular diseases. Different studies suggest that obesity together with a high-fat diet are related to the production of remodeling factors associated with expression and distribution of Cx43 in the atrium.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
New Evidence on BPA’s Role in Adipose Tissue Development of Proinflammatory Processes and Its Relationship with Obesity (2024)
González-Casanova, Jorge Enrique; Bermúdez, Valmore; Caro Fuentes, Nelson Javier; Angarita, Lissé Chiquinquirá; Caicedo, Nelson Hernando; Rivas Muñoz, Jocelyn; Rojas-Gómez, Diana Marcela (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Bisphenol A (BPA) is a xenobiotic with endocrine disruptor properties which interacts with various receptors, eliciting a cellular response. In the plastic industry, BPA is widely used in the production of polycarbonate ... -
Article
Antimicrobial and antibiofilm capacity of chitosan nanoparticles against wild type strain of pseudomonas sp. Isolated from milk of cows diagnosed with bovine mastitis (2020)
Aguayo, Paula Rivera; Larenas, Tamara Bruna; Godoy, Carlos Alarcón; Rivas, Bernardita Cayupe; González-Casanova, Jorge Enrique; Rojas-Gómez, Diana Marcela; Fuentes, Nelson Caro (MDPI AG, 2020-08-28)Bovine mastitis (BM) is the most prevalent bacterial infection in the livestock sector, affecting the dairy industry greatly. The prevention and treatment of this disease is mainly made via antibiotics, but the increasing ... -
Article
An update on connexin gap junction and hemichannels in diabetic retinopathy (2021)
González-Casanova, Jorge Enrique; Schmachtenberg, Oliver; Martínez, Agustín D.; Sánchez, Helmuth A.; Harcha, Paloma Andrea; Rojas-Gómez, Diana Marcela (MDPI AG, 2021-03-02)Diabetic retinopathy (DR) is one of the main causes of vision loss in the working age population. It is characterized by a progressive deterioration of the retinal microvasculature, caused by long-term metabolic alterations ...