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Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure
dc.contributor.author | Schwarz, Karla G. | |
dc.contributor.author | Pereyra, Katherin V. | |
dc.contributor.author | Toledo, Camilo | |
dc.contributor.author | Andrade, David Cristóbal | |
dc.contributor.author | Díaz, Hugo S. | |
dc.contributor.author | Díaz-Jara, Esteban | |
dc.contributor.author | Ortolani, Domiziana | |
dc.contributor.author | Ríos-Gallardo, Angélica P. | |
dc.contributor.author | Arias, Paulina | |
dc.contributor.author | las Heras, Alexandra | |
dc.contributor.author | Vera, Ignacio | |
dc.contributor.author | Ortiz, Fernando C. | |
dc.date.accessioned | 2022-01-18T12:28:43Z | |
dc.date.available | 2022-01-18T12:28:43Z | |
dc.date.issued | 2021-12 | |
dc.identifier | 10.1186/s40659-021-00365-z | |
dc.identifier.issn | 07169760 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/9868 | |
dc.description.abstract | Background: Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K+) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K+ consumption may exert similar effects in CHF has not been previously tested. Accordingly, we aimed to evaluate the effects of dietary K+ supplementation on cardiorespiratory alterations in rats with CHF. Methods: Adult male Sprague–Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K+ diet (CHF+K+ group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outflow, baroreflex sensitivity, breathing disorders, chemoreflex function, respiratory–cardiovascular coupling and cardiac function were evaluated. Results: Compared to normal chow diet, K+ supplemented diet in CHF significantly reduced arrhythmia incidence (67.8 ± 15.1 vs. 31.0 ± 3.7 events/hour, CHF vs. CHF+K+), decreased cardiac sympathetic tone (ΔHR to propranolol: − 97.4 ± 9.4 vs. − 60.8 ± 8.3 bpm, CHF vs. CHF+K+), restored baroreflex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K+ restores normal central respiratory chemoreflex drive and abrogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function. Conclusion: Our findings support that dietary K+ supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | BioMed Central Ltd | es_ES |
dc.subject | Autonomic imbalance | es_ES |
dc.subject | Breathing disorders | es_ES |
dc.subject | Chemoreflex function | es_ES |
dc.subject | Heart failure | es_ES |
dc.subject | Potassium supplemented diet | es_ES |
dc.title | Effects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failure | es_ES |
dc.type | Article | es_ES |