Association between arterial stiffness and the clustering of metabolic syndrome risk factors: a systematic review and meta-analysis
Autor
Sequí-Domínguez, Irene
Cavero-Redondo, Iván
Álvarez-Bueno, Celia
Saz-Lara, Alicia
Mesas, A. E.
Martinez Vizcaino, Vicente J.
Resumen
OBJECTIVES: Metabolic syndrome (MetS) is a cluster of different cardiometabolic risk factors (CMRFs), and its different combinations with other CMRFs, such as arterial stiffness have been hypothesized to explain, at least partially, increased risk of cardiovascular disease. Thus, in this systematic review and meta-analysis, we aimed to synthesize the evidence regarding the association between the clustering of MetS-related CMRFs and arterial stiffness measured using pulse wave velocity (PWV). METHODS: Original studies analysing the association between arterial stiffness, measured using PWV, and MetS were systematically searched. Pooled effect size estimates and their respective 95% confidence intervals (CI) were calculated using the DerSimonian and Laird method for two separate analyses: the diagnosis of MetS and PWV values and the number of CMRFs and PWV values. RESULTS: Moderate effect size estimates were observed between MetS and PWV (0.68, 95% CI: 0.54-0.82) with a slightly higher effect size for the low-risk compared with the high-risk population group (0.75, 95% CI: 0.58-0.92; and 0.51, 95% CI: 0.32-0.82, respectively). A trend between the number of MetS-related CMRFs and PWV was found with the pooled effect size nearly doubling as the number of MetS-related CMRFs increased, 0.11 (95% CI: 0.04-0.17) for one MetS-related CMRF, 0.26 (95% CI: 0.13-0.4) for two, and 0.4 (95% CI: 0.2-0.6) for three or more. CONCLUSION: These results demonstrated a clinically relevant association between MetS and PWV and an increasing trend in PWV values, such as a MetS-related CMRF increase. Although these results should be considered cautiously because of the considerable heterogeneity, our findings reinforce the rationale of MetS as an aggregation of risk factors with common causes, which could provide additional useful information to guide clinical management.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Association Between Arterial Stiffness and Blood Pressure Progression With Incident Hypertension: A Systematic Review and Meta-Analysis (2024)
Saz-Lara, Alicia; Bruno, Rosa María; Cavero-Redondo, Iván; Álvarez-Bueno, Celia; Notario-Pacheco, Blanca; Martínez-Vizcaíno, Vicente (Frontiers Media S.A., 2022)Background: Arterial stiffness is an independent predictor of cardiovascular and all-cause mortality that is classically regarded as a consequence of arterial hypertension. However, a growing number of studies have shown ... -
Article
Association between arterial stiffness and orthostatic hypotension: A systematic review and meta-analysis (2024)
Saz-Lara, Alicia; Cavero-Redondo, Iván; Martínez-Vizcaíno, Vicente; Lucerón-Lucas-Torres, Maribel; Pascual-Morena, Carlos; Sequí-Domínguez, Irese (Frontiers Media S.A., 2023)Background: Orthostatic hypotension, defined as a decrease in blood pressure on standing, is associated with an increased risk of mortality and cardiovascular events in the general population. In addition, it has recently ... -
Article
Association between severe hypoglycaemia and risk of dementia in patients with type 2 diabetes mellitus: A systematic review and meta-analysis (2023)
Gómez-Guijarro, María Dolores; Álvarez-Bueno, Celia; Saz-Lara, Alicia; Sequí-Domínguez, Irene; Lucerón-Lucas-Torres, Maribel; Cavero-Redondo, Iván (John Wiley and Sons Ltd, 2023)The aim of this systematic review was to analyse whether there is an association between severe hypoglycaemia and the incidence of dementia in patients with type 2 diabetes mellitus. We systematically searched the MEDLINE, ...