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Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients
dc.contributor.author | Blauensteiner, J. | |
dc.contributor.author | Bertinat, Romina | |
dc.contributor.author | León, Luis E. | |
dc.contributor.author | Riederer, Monika | |
dc.contributor.author | Sepúlveda, Nuno | |
dc.contributor.author | Westermeier, Francisco | |
dc.date.accessioned | 2021-06-02T02:38:53Z | |
dc.date.available | 2021-06-02T02:38:53Z | |
dc.date.issued | 2021-12 | |
dc.identifier | 10.1038/s41598-021-89834-9 | |
dc.identifier.issn | 20452322 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/8894 | |
dc.description.abstract | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by unexplained debilitating fatigue. Although the etiology is unknown, evidence supports immunological abnormalities, such as persistent inflammation and immune-cell activation, in a subset of patients. Since the interplay between inflammation and vascular alterations is well-established in other diseases, endothelial dysfunction has emerged as another player in ME/CFS pathogenesis. Endothelial nitric oxide synthase (eNOS) generates nitric oxide (NO) that maintains endothelial homeostasis. eNOS is activated by silent information regulator 1 (Sirt1), an anti-inflammatory protein. Despite its relevance, no study has addressed the Sirt1/eNOS axis in ME/CFS. The interest in circulating microRNAs (miRs) as potential biomarkers in ME/CFS has increased in recent years. Accordingly, we analyze a set of miRs reported to modulate the Sirt1/eNOS axis using plasma from ME/CFS patients. Our results show that miR-21, miR-34a, miR-92a, miR-126, and miR-200c are jointly increased in ME/CFS patients compared to healthy controls. A similar finding was obtained when analyzing public miR data on peripheral blood mononuclear cells. Bioinformatics analysis shows that endothelial function-related signaling pathways are associated with these miRs, including oxidative stress and oxygen regulation. Interestingly, histone deacetylase 1, a protein responsible for epigenetic regulations, represented the most relevant node within the network. In conclusion, our study provides a basis to find endothelial dysfunction-related biomarkers and explore novel targets in ME/CFS. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Nature Research | es_ES |
dc.title | Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients | es_ES |
dc.type | Article | es_ES |