Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients
Autor
Blauensteiner, J.
Bertinat, Romina
León, Luis E.
Riederer, Monika
Sepúlveda, Nuno
Westermeier, Francisco
Resumen
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by unexplained debilitating fatigue. Although the etiology is unknown, evidence supports immunological abnormalities, such as persistent inflammation and immune-cell activation, in a subset of patients. Since the interplay between inflammation and vascular alterations is well-established in other diseases, endothelial dysfunction has emerged as another player in ME/CFS pathogenesis. Endothelial nitric oxide synthase (eNOS) generates nitric oxide (NO) that maintains endothelial homeostasis. eNOS is activated by silent information regulator 1 (Sirt1), an anti-inflammatory protein. Despite its relevance, no study has addressed the Sirt1/eNOS axis in ME/CFS. The interest in circulating microRNAs (miRs) as potential biomarkers in ME/CFS has increased in recent years. Accordingly, we analyze a set of miRs reported to modulate the Sirt1/eNOS axis using plasma from ME/CFS patients. Our results show that miR-21, miR-34a, miR-92a, miR-126, and miR-200c are jointly increased in ME/CFS patients compared to healthy controls. A similar finding was obtained when analyzing public miR data on peripheral blood mononuclear cells. Bioinformatics analysis shows that endothelial function-related signaling pathways are associated with these miRs, including oxidative stress and oxygen regulation. Interestingly, histone deacetylase 1, a protein responsible for epigenetic regulations, represented the most relevant node within the network. In conclusion, our study provides a basis to find endothelial dysfunction-related biomarkers and explore novel targets in ME/CFS.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Publisher Correction: Altered endothelial dysfunction-related miRs in plasma from ME/CFS patients (Scientific Reports, (2021), 11, 1, (10604), 10.1038/s41598-021-89834-9) (2021)
Blauensteiner, J.; Bertinat, Romina; León, Luis E.; Riederer, Monika; Sepúlveda, Nuno; Westermeier, Francisco (Nature Research, 2021-12)The original version of this Article contained errors. Affiliation 5 was incorrectly given as ‘Centro de Estatística e Aplicações, Universidade de Lisboa, Lisbon, Portugal’. The correct affiliation is listed below. ‘CEAUL ... -
Review
Enhanced carotid body chemosensory activity and the cardiovascular alterations induced by intermittent hypoxia (2020)
Iturriaga R.; Andrade D.C.; Del Rio R. (Frontiers Media S.A., 2014) -
Review
Endothelial PPARγ Is Crucial for Averting Age-Related Vascular Dysfunction by Stalling Oxidative Stress and ROCK (2020)
Uddin M.S.; Kabir M.T.; Jakaria M.; Mamun A.A.; Niaz K.; Amran M.S.; Barreto G.E.; Ashraf G.M. (Springer New York LLC, 2019)