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Consumption of a calafate (Berberis microphylla) extract of modifies markers of immune respo NSE in lean and obese mice
dc.contributor.author | Concha F., Francisca | |
dc.contributor.author | Villanueva V., Vanessa | |
dc.contributor.author | Vasquez, Karla | |
dc.contributor.author | Orellana, Juan Francisco | |
dc.contributor.author | Escobillana, Lucas | |
dc.contributor.author | Mendez, Aline | |
dc.contributor.author | Soto, Misare | |
dc.contributor.author | Stevenson, Andres | |
dc.contributor.author | Meneses, Paz | |
dc.contributor.author | Cid, Valentina | |
dc.contributor.author | Delgado M., Monserrat | |
dc.contributor.author | Fuenzalida, Loreto F. | |
dc.contributor.author | Garcia-Diaz, Diego F. | |
dc.date.accessioned | 2021-03-24T14:43:25Z | |
dc.date.available | 2021-03-24T14:43:25Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.4067/S0717-75182021000100051 | |
dc.identifier.issn | 07177518 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/8734 | |
dc.description.abstract | Obesity has been identified as a risk factor for severity of respiratory infections. Thus, the support of the immune response in obese subjects is of interest. The present work evaluated the effect of the consumption of a calafate extract on markers of the immune response in lean and obese mice. Male C57BL/6J mice were exposed for 82 days to a standard or a high-fat diet (HFD). A subgroup of both groups was given 50 and 100 mg [total polyphenols]/kg body weight/day of extract in the last two weeks. Gene expression and secretion of immune response markers were evaluated in lung tissue and plasma. An effect of extract treatment on IFN-ϓ expression was observed. Effects induced by the HFD and treatment with extract were observed independent of the expression of IL-12. An overall effect of the HF diet on plasma IFN-ϓ was observed, specifically a decrease in animals fed the HFD. An interaction between diet and extract treatment was observed over plasma IL-12. The treatment used modulates markers that activate the immune response to respiratory infections, mainly of viral origin, in lean and obese animals. | es_ES |
dc.language.iso | es | es_ES |
dc.publisher | Sociedad Chilena de Nutricion Bromatologia y Toxilogica | es_ES |
dc.subject | Anti-viral response | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Polyphenols | es_ES |
dc.title | Consumption of a calafate (Berberis microphylla) extract of modifies markers of immune respo NSE in lean and obese mice | es_ES |
dc.title.alternative | El consumo de un extracto de calafate (Berberis microphylla) modifica marcadores de respuesta inmune en ratones delgados y obesos | es_ES |
dc.type | Article | es_ES |