Consumption of a calafate (Berberis microphylla) extract of modifies markers of immune respo NSE in lean and obese mice
Autor
Concha F., Francisca
Villanueva V., Vanessa
Vasquez, Karla
Orellana, Juan Francisco
Escobillana, Lucas
Mendez, Aline
Soto, Misare
Stevenson, Andres
Meneses, Paz
Cid, Valentina
Delgado M., Monserrat
Fuenzalida, Loreto F.
Garcia-Diaz, Diego F.
Resumen
Obesity has been identified as a risk factor for severity of respiratory infections. Thus, the support of the immune response in obese subjects is of interest. The present work evaluated the effect of the consumption of a calafate extract on markers of the immune response in lean and obese mice. Male C57BL/6J mice were exposed for 82 days to a standard or a high-fat diet (HFD). A subgroup of both groups was given 50 and 100 mg [total polyphenols]/kg body weight/day of extract in the last two weeks. Gene expression and secretion of immune response markers were evaluated in lung tissue and plasma. An effect of extract treatment on IFN-ϓ expression was observed. Effects induced by the HFD and treatment with extract were observed independent of the expression of IL-12. An overall effect of the HF diet on plasma IFN-ϓ was observed, specifically a decrease in animals fed the HFD. An interaction between diet and extract treatment was observed over plasma IL-12. The treatment used modulates markers that activate the immune response to respiratory infections, mainly of viral origin, in lean and obese animals.
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