Mostrar el registro sencillo del ítem

Programming of dopaminergic neurons by early exposure to sex hormones: Effects on morphine-induced accumbens dopamine release, reward, and locomotor behavior in male and female rats

dc.contributor.authorVelásquez V.B.
dc.contributor.authorZamorano G.A.
dc.contributor.authorMartínez-Pinto J.
dc.contributor.authorBonansco C.
dc.contributor.authorJara P.
dc.contributor.authorTorres G.E.
dc.contributor.authorRenard G.M.
dc.contributor.authorSotomayor-Zárate R.
dc.date.accessioned2020-09-02T22:29:59Z
dc.date.available2020-09-02T22:29:59Z
dc.date.issued2019
dc.identifier10.3389/fphar.2019.00295
dc.identifier.citation10, MAR, -
dc.identifier.issn16639812
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6541
dc.descriptionNeonatal programming with sex hormones produces long-term functional changes in various tissues, including the brain. Previously, we demonstrated a higher content of dopamine and an increase in potassium-induced dopamine release in the nucleus accumbens of adult rats exposed to estradiol valerate. On the other hand, sex hormones also affect the opioid system increasing the expression of the μ opioid receptor and β-endorphins. Here, we investigated if neonatal programming with sex hormones alters the response to morphine during adulthood in rats and predispose them to neurochemical, rewarding and behavioral activating effects. We examined the effects of neonatal exposure to a single dose of estradiol valerate or testosterone propionate on morphine-induced (5 mg/kg, i.v.) dopamine release in the nucleus accumbens and morphine-induced (3 mg/kg, s.c.) locomotor activity and conditioned place preference when these rats were adults. Our results showed a significant increase in morphine-induced dopamine release in the nucleus accumbens of rats that were exposed neonatally to estradiol compared with control rats. This effect was correlated with higher place preference and locomotor activity induced by morphine in adult rats neonatally exposed to estradiol valerate. However, the effect of morphine on dopamine release and behaviors was similar in rats treated with testosterone compared to control rats. Additionally, the expression of mu (μ) opioid receptor, dopamine receptor type 1 (D1) and dopamine receptor type 2 (D2) in the nucleus accumbens of adult rats was not different after treatment with sex hormones. Taken together, our results demonstrated an enhancement of pharmacological effects produced by morphine in rats neonatally programmed with estradiol valerate, suggesting that early exposure to sex hormones could represent a vulnerability factor in the development of addiction to opioid drugs such as morphine and heroin in adulthood. © 2019 Velásquez, Zamorano, Martínez-Pinto, Bonansco, Jara, Torres, Renard and Sotomayor-Zárate.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectDopamine
dc.subjectEstradiol
dc.subjectMicrodialysis
dc.subjectMorphine
dc.subjectNucleus accumbens
dc.subjectProgramming
dc.subjectTestosterone
dc.subjectdopamine
dc.subjectdopamine 1 receptor
dc.subjectdopamine 2 receptor
dc.subjectestradiol valerate
dc.subjectmorphine
dc.subjectmu opiate receptor
dc.subjectsex hormone
dc.subjecttestosterone propionate
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcorrelational study
dc.subjectdopamine release
dc.subjectdopaminergic nerve cell
dc.subjectdrug effect
dc.subjectexposure
dc.subjectfemale
dc.subjectlocomotion
dc.subjectmale
dc.subjectneurochemistry
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectnuclear reprogramming
dc.subjectnucleus accumbens
dc.subjectplace preference
dc.subjectprotein expression
dc.subjectrat
dc.subjectreward
dc.titleProgramming of dopaminergic neurons by early exposure to sex hormones: Effects on morphine-induced accumbens dopamine release, reward, and locomotor behavior in male and female rats
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85066450044.pdf
Tamaño:
3.697Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem