UFR2709, a nicotinic acetylcholine receptor antagonist, decreases ethanol intake in alcohol-preferring rats
Autor
Quiroz G.
Sotomayor-Zárate R.
González-Gutierrez J.P.
Vizcarra F.
Moraga F.
Bermudez I.
Reyes-Parada M.
Quintanilla M.E.
Lagos D.
Rivera-Meza M.
Iturriaga-Vásquez P.
Resumen
Brain nicotinic acetylcholine receptors (nAChRs), a heterogeneous family of pentameric acetylcholine-gated cation channels, have been suggested as molecular targets for the treatment of alcohol abuse and dependence. Here, we examined the effect of the competitive nAChR antagonist UFR2709 on the alcohol consumption of high-alcoholdrinking UChB rats. UChB rats were given free access to ethanol for 24-h periods in a two-bottle free choice paradigm and their ethanol and water intake were measured. The animals were i.p. injected daily for 17 days with a 10, 5, 2.5, or 1 mg/kg dose of UFR2709. Potential confounding motor effects of UFR2709 were assessed by examining the locomotor activity of animals administered the highest dose of UR2709 tested (10 mg/kg i.p.). UFR2709 reduced ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 was 2.5 mg/kg, which induced a 56% reduction in alcohol consumption. Administration of UFR2709 did not affect the weight or locomotor activity of the rats, suggesting that its effects on alcohol consumption and preference were mediated by specific nAChRs. Copyright © 2019 Quiroz, Sotomayor-Zárate, González-Gutierrez, Vizcarra, Moraga, Bermudez, Reyes-Parada, Quintanilla, Lagos, Rivera-Meza and Iturriaga-Vásquez.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats (2022)
Gálvez, Gabriel; González-Gutiérrez, Juan Pablo; Hödar-Salazar, Martín; Sotomayor-Zárate, Ramón; Quintanilla, María Elena; Quilaqueo, María Elena; Rivera-Meza, Mario; Iturriaga-Vásquez, Patricio (MDPI, 2022-07)Alcoholism is a worldwide public health problem with high economic cost and which affects health and social behavior. It is estimated that alcoholism kills 3 million people globally, while in Chile it is responsible for ... -
Article
Nicotinic antagonist UFR2709 inhibits nicotine reward and decreases anxiety in Zebrafish (2020)
Viscarra F.; González-Gutierrez J.; Esparza E.; Figueroa C.; Paillali P.; Hödar-Salazar M.; Cespedes C.; Quiroz G.; Sotomayor-Zárate R.; Reyes-Parada M.; ... (MDPI AG, 2020) -
Article
Synthesis of novel nicotinic ligands with multimodal action: Targeting Acetylcholine α4β2, Dopamine and Serotonin Transporters (2020)
González-Gutiérrez J.P.; Pessoa-Mahana H.A.; Iturriaga-Vásquez P.E.; Reyes-Parada M.I.; Guerra-Díaz N.E.; Hodar-Salazar M.; Viscarra F.; Paillali P.; Núñez-Vivanco G.; Lorca-Carvajal M.A.; ... (MDPI AG, 2019)