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Co-administration of TiO2 nanowired cerebrolysin and alpha-melanocyte stimulating hormone has superior neuroprotective effects on brain pathology following concussive head injury after Sleep deprivation

dc.contributor.authorSharma A.
dc.contributor.authorMuresanu D.F.
dc.contributor.authorLafuente J.V.
dc.contributor.authorNozari A.
dc.contributor.authorPatnaik R.
dc.contributor.authorOzkizilcik A.
dc.contributor.authorTian Z.R.
dc.contributor.authorMössier H.
dc.contributor.authorSharma H.S.
dc.date.accessioned2020-09-02T22:28:13Z
dc.date.available2020-09-02T22:28:13Z
dc.date.issued2018
dc.identifier.citation3, , 77-80
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6243
dc.descriptionSleep deprivation (SD) is a serious problem in military personnel during combat operations. Previous observations from our laboratory showed marked brain pathology following SD in rats from 12 h to 72 h in a progressive manner. In this innovation we demonstrate that a an additional concussive head injury (CHI) that is very common in soldiers during combat operation could exacerbate SD induced brain damage and behavioral dysfunction. We found a several fold increase in BBB permeability to Evans blue albumin (EBA) and radioiodine ([131]-I), brain edema in several brain regions associated with neuronal injuries after CHI in SD at 48 h. Interestingly, the brain derived neurotrophic factor (BDNF) levels and alpha-melanocyte stimulating hormone (α-MSH) showed greater decline in CHI animals after SD. Thus, TiO2 nanowired tdelivery of cerebrolysin (2.5 ml/kg, i.v.) together with α-MSH 4 to 6 h after CHI in SD significantly increased BDNF and α-MSH levels and reduced brain pathology seen at 48 h. This treatment also improved behavioral functions significantly in CHI rats after SD. These observations are the first to show that nanodelivery of cerebrolysin with a-MSH has superior neuroprotective effects in SD following CHI, not reported earlier. © 2018 OOSV. All rights reserved.
dc.language.isoen
dc.publisherTechConnect
dc.sourceRomanowicz B.Case F.Case F.Laudon M.
dc.subjectBrain derived neurotrophic factor
dc.subjectBrain pathology
dc.subjectCerebrolsyin
dc.subjectConcussive head injury
dc.subjectSleep deprivation in military
dc.subjectTiO2 nanowired delivery
dc.subjectα-MSH
dc.subjectBrain
dc.subjectPathology
dc.subjectRats
dc.subjectSleep research
dc.subjectTitanium dioxide
dc.subjectBrain pathologies
dc.subjectBrain-derived neurotrophic factors
dc.subjectCerebrolsyin
dc.subjectHead injuries
dc.subjectSleep deprivation
dc.subjectTiO2 nanowired delivery
dc.subjectCobalt compounds
dc.titleCo-administration of TiO2 nanowired cerebrolysin and alpha-melanocyte stimulating hormone has superior neuroprotective effects on brain pathology following concussive head injury after Sleep deprivation
dc.typeConference Paper


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