Co-administration of TiO2 nanowired cerebrolysin and alpha-melanocyte stimulating hormone has superior neuroprotective effects on brain pathology following concussive head injury after Sleep deprivation
Autor
Sharma A.
Muresanu D.F.
Lafuente J.V.
Nozari A.
Patnaik R.
Ozkizilcik A.
Tian Z.R.
Mössier H.
Sharma H.S.
Resumen
Sleep deprivation (SD) is a serious problem in military personnel during combat operations. Previous observations from our laboratory showed marked brain pathology following SD in rats from 12 h to 72 h in a progressive manner. In this innovation we demonstrate that a an additional concussive head injury (CHI) that is very common in soldiers during combat operation could exacerbate SD induced brain damage and behavioral dysfunction. We found a several fold increase in BBB permeability to Evans blue albumin (EBA) and radioiodine ([131]-I), brain edema in several brain regions associated with neuronal injuries after CHI in SD at 48 h. Interestingly, the brain derived neurotrophic factor (BDNF) levels and alpha-melanocyte stimulating hormone (α-MSH) showed greater decline in CHI animals after SD. Thus, TiO2 nanowired tdelivery of cerebrolysin (2.5 ml/kg, i.v.) together with α-MSH 4 to 6 h after CHI in SD significantly increased BDNF and α-MSH levels and reduced brain pathology seen at 48 h. This treatment also improved behavioral functions significantly in CHI rats after SD. These observations are the first to show that nanodelivery of cerebrolysin with a-MSH has superior neuroprotective effects in SD following CHI, not reported earlier. © 2018 OOSV. All rights reserved.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Conference Paper
TiO2-nanowired delivery of cerebrolysin thwarts exacerbation of sleep deprivation induced decline in regional brain derived neurotrophic factor, brain pathology and behavioral dysfunctions following emotional stress (2020)
Sharma A.; Muresanu D.F.; Lamente J.V.; Nozari A.; Patnaik R.; Ozkizilcik A.; Tian Z.R.; Mossier H.; Sharma H.S. (TechConnect, 2017) -
Article
Nanowired Delivery of Growth Hormone Attenuates Pathophysiology of Spinal Cord Injury and Enhances Insulin-Like Growth Factor-1 Concentration in the Plasma and the Spinal Cord (2020)
Muresanu D.F.; Sharma A.; Lafuente J.V.; Patnaik R.; Tian Z.R.; Nyberg F.; Sharma H.S. (Humana Press Inc., 2015) -
Review
Pathophysiology of blood-brain barrier in brain injury in cold and hot environments: Novel drug targets for neuroprotection (2020)
Sharma H.S.; Muresanu D.F.; Lafuente J.V.; Nozari A.; Patnaik R.; Skaper S.D.; Sharma A. (Bentham Science Publishers B.V., 2016)