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Celecoxib/PLGA suppresses angiogenesis and lung metastasis of murine experimental breast cancer [Celecoxib/PLGA suprime angiogénesis y metástasis pulmonar de un cáncer mamario murino experimental]

dc.contributor.authorRoa I.
dc.contributor.authorCantín M.
dc.contributor.authorMuñoz M.
dc.contributor.authorRosas C.
dc.contributor.authorLemus D.
dc.date.accessioned2020-09-02T22:27:02Z
dc.date.available2020-09-02T22:27:02Z
dc.date.issued2016
dc.identifier10.4067/S0717-95022016000100048
dc.identifier.citation34, 1, 335-341
dc.identifier.issn07179367
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6029
dc.descriptionAngiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aimwas to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice.An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E andArteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable to other tumor lines, concluding that Celecoxib/poli(lactic-co-glycolic) acid is a potential candidate in antitumor therapy. © 2016, Universidad de la Frontera. All rights reserved.
dc.language.isoes
dc.publisherUniversidad de la Frontera
dc.subjectAngiogenesis
dc.subjectCancer
dc.subjectCelecoxib
dc.subjectLung
dc.subjectMetastasis
dc.subjectPLGA
dc.titleCelecoxib/PLGA suppresses angiogenesis and lung metastasis of murine experimental breast cancer [Celecoxib/PLGA suprime angiogénesis y metástasis pulmonar de un cáncer mamario murino experimental]
dc.typeArticle


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