Celecoxib/PLGA suppresses angiogenesis and lung metastasis of murine experimental breast cancer [Celecoxib/PLGA suprime angiogénesis y metástasis pulmonar de un cáncer mamario murino experimental]
Autor
Roa I.
Cantín M.
Muñoz M.
Rosas C.
Lemus D.
Resumen
Angiogenesis and metastasis are critical events on the tumor invasion process. Their close association is related as a good target in antitumor therapy. The aimwas to analyze lung metastasis pattern and angiogenesis following application of microencapsulated Celecoxib with poli(lactic-co-glycolic) acid in mice.An experimental tumor model was assessed, induced by TA3-MTX-R cells, in 18 mice, separated in 3 groups of 6 animals and treated with 2 intramuscular Celecoxib presentations (Group Control; Group Cx 1000 ppm and Group Cx 1000 ppm+PLGA). Mice were sacrificed and histologically processed to stain slides with H&E andArteta Trichromic. The study revealed that the lung showed a significant heterogeneity, and a perivascular metastasis pattern; moreover, Celecoxib associated to poli(lactic-co-glycolic) acid reduces tumor invasion and pulmonary angiogenesis. The results are similar to partial previous descriptions and are comparable to other tumor lines, concluding that Celecoxib/poli(lactic-co-glycolic) acid is a potential candidate in antitumor therapy. © 2016, Universidad de la Frontera. All rights reserved.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Review
Brown seaweed fucoidan in cancer: Implications in metastasis and drug resistance (2020)
Reyes M.E.; Riquelme I.; Salvo T.; Zanella L.; Letelier P.; Brebi P. (MDPI AG, 2020) -
Article
Epigenetic modulation of cytokine expression in gastric cancer: influence on angiogenesis, metastasis and chemoresistance (2024)
Reyes, María Elena; Pulgar, Victoria; Vivallo, Carolina; Ili, Carmen Gloria; Mora-Lagos, Bárbara; Brebi, Priscilla (Frontiers Media SA, 2024)Cytokines are proteins that act in the immune response and inflammation and have been associated with the development of some types of cancer, such as gastric cancer (GC). GC is a malignant neoplasm that ranks fifth in ... -
Article
Familial polythelia associated with dental anomalies: A case report [Politelia familiar asociada con anomalías dentarias: Un caso clínico] (2020)
Fonseca G.M.; Cantín M. (Facultad de Salud de la Universidad del Valle, 2014)