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Amphetamine derivatives as monoamine oxidase inhibitors
dc.contributor.author | Reyes-Parada M. | |
dc.contributor.author | Iturriaga-Vasquez P. | |
dc.contributor.author | Cassels B.K. | |
dc.date.accessioned | 2020-09-02T22:26:59Z | |
dc.date.available | 2020-09-02T22:26:59Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.3389/fphar.2019.01590 | |
dc.identifier.citation | 10, , - | |
dc.identifier.issn | 16639812 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/6012 | |
dc.description | Amphetamine and its derivatives exhibit a wide range of pharmacological activities, including psychostimulant, hallucinogenic, entactogenic, anorectic, or antidepressant effects. The mechanisms of action underlying these effects are usually related to the ability of the different amphetamines to interact with diverse monoamine transporters or receptors. Moreover, many of these compounds are also potent and selective monoamine oxidase inhibitors. In the present work, we review how structural modifications on the aromatic ring, the amino group and/or the aliphatic side chain of the parent scaffold, modulate the enzyme inhibitory properties of hundreds of amphetamine derivatives. Furthermore, we discuss how monoamine oxidase inhibition might influence the pharmacology of these compounds. © 2020 Royal Society of Chemistry. All rights reserved. | |
dc.language.iso | en | |
dc.publisher | Frontiers Media S.A. | |
dc.subject | Amphetamine derivatives | |
dc.subject | Dopamine transporter | |
dc.subject | Monoamine oxidase | |
dc.subject | Monoamine oxidase-A | |
dc.subject | Norepinephrine transporter | |
dc.subject | Serotonin syndrome | |
dc.subject | Serotonin transporter | |
dc.subject | 2,6 dichloro 4 dimethylaminoamphetamine | |
dc.subject | 4 iodo 2,5 dimethoxyamphetamine | |
dc.subject | aliphatic compound | |
dc.subject | amiflamine | |
dc.subject | amine oxidase (flavin containing) | |
dc.subject | amino acid derivative | |
dc.subject | amphetamine derivative | |
dc.subject | aromatic compound | |
dc.subject | cathinone | |
dc.subject | fenfluramine | |
dc.subject | fla 289 | |
dc.subject | fla 314 | |
dc.subject | fla 384 | |
dc.subject | fla 405 | |
dc.subject | fla 450 | |
dc.subject | fla 463 | |
dc.subject | fla 558 | |
dc.subject | fla 717 | |
dc.subject | fla 727 | |
dc.subject | fla 788 | |
dc.subject | methamphetamine | |
dc.subject | monoamine oxidase A inhibitor | |
dc.subject | monoamine oxidase B inhibitor | |
dc.subject | monoamine oxidase inhibitor | |
dc.subject | phenethylamine | |
dc.subject | phentermine | |
dc.subject | serotonin receptor | |
dc.subject | unclassified drug | |
dc.subject | antidepressant activity | |
dc.subject | Article | |
dc.subject | binding affinity | |
dc.subject | chemical modification | |
dc.subject | drug binding site | |
dc.subject | drug identification | |
dc.subject | drug potency | |
dc.subject | drug receptor binding | |
dc.subject | drug targeting | |
dc.subject | enantioselectivity | |
dc.subject | enzyme inhibition | |
dc.subject | human | |
dc.subject | molecular docking | |
dc.subject | nonhuman | |
dc.subject | structure activity relation | |
dc.subject | structure analysis | |
dc.subject | tranquilizing activity | |
dc.title | Amphetamine derivatives as monoamine oxidase inhibitors | |
dc.type | Article |