Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying Affinity for 5-HT1AR/SERT
Autor
Pessoa-Mahana H.
Silva-Matus P.
Pessoa-Mahana C.D.
Chung H.
Iturriaga-Vásquez P.
Quiroz G.
Möller-Acuña P.
Zapata-Torres G.
Saitz-Barría C.
Araya-Maturana R.
Reyes-Parada M.
Resumen
A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1AR (Ki = 43 and 56 nM), whereas compounds 11c and 14a were the most potent analogs at the SERT (Ki = 34 and 17 nM). On the other hand, compounds 14b and 11d showed potent activity at both targets, displaying a profile that makes them promising leads for the search for novel potent ligands with a dual mechanism of action. Molecular docking studies in all the compounds unveiled relevant drug–target interactions, which allowed rationalizing the observed affinities. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Synthesis, docking and pharmacological evaluation of novel homo- and hetero-bis 3-piperazinylpropylindole derivatives at SERT and 5-HT1A receptor (2020)
Pessoa-Mahana H.; González-Lira C.; Fierro A.; Zapata-Torres G.; Pessoa-Mahana C.D.; Ortiz-Severin J.; Iturriaga-Vásquez P.; Reyes-Parada M.; Silva-Matus P.; Saitz-Barría C.; ... (2013) -
Article
Synthesis, 5-hydroxytryptamine1A receptor affinity and docking studies of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives (2020)
Pessoa-Mahana H.; Núñez C.U.; Araya-Maturana R.; Barría C.S.; Zapata-Torres G.; Pessoa-Mahana C.D.; Iturriaga-Vasquez P.; Mella-Raipán J.; Reyes-Parada M.; Celis-Barros C. (Pharmaceutical Society of Japan, 2012) -
Article
Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease (2020)
Rodríguez-Lavado J.; Gallardo-Garrido C.; Mallea M.; Bustos V.; Osorio R.; Hödar-Salazar M.; Chung H.; Araya-Maturana R.; Lorca M.; Pessoa-Mahana C.D.; ... (Elsevier Masson SAS, 2020)