Mostrar el registro sencillo del ítem

UFR2709, a nicotinic acetylcholine receptor antagonist, decreases ethanol intake in alcohol-preferring rats

dc.contributor.authorQuiroz G.
dc.contributor.authorSotomayor-Zárate R.
dc.contributor.authorGonzález-Gutierrez J.P.
dc.contributor.authorVizcarra F.
dc.contributor.authorMoraga F.
dc.contributor.authorBermudez I.
dc.contributor.authorReyes-Parada M.
dc.contributor.authorQuintanilla M.E.
dc.contributor.authorLagos D.
dc.contributor.authorRivera-Meza M.
dc.contributor.authorIturriaga-Vásquez P.
dc.date.accessioned2020-09-02T22:26:29Z
dc.date.available2020-09-02T22:26:29Z
dc.date.issued2019
dc.identifier10.3389/fphar.2019.01429
dc.identifier.citation10, , -
dc.identifier.issn16639812
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5933
dc.descriptionBrain nicotinic acetylcholine receptors (nAChRs), a heterogeneous family of pentameric acetylcholine-gated cation channels, have been suggested as molecular targets for the treatment of alcohol abuse and dependence. Here, we examined the effect of the competitive nAChR antagonist UFR2709 on the alcohol consumption of high-alcoholdrinking UChB rats. UChB rats were given free access to ethanol for 24-h periods in a two-bottle free choice paradigm and their ethanol and water intake were measured. The animals were i.p. injected daily for 17 days with a 10, 5, 2.5, or 1 mg/kg dose of UFR2709. Potential confounding motor effects of UFR2709 were assessed by examining the locomotor activity of animals administered the highest dose of UR2709 tested (10 mg/kg i.p.). UFR2709 reduced ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 was 2.5 mg/kg, which induced a 56% reduction in alcohol consumption. Administration of UFR2709 did not affect the weight or locomotor activity of the rats, suggesting that its effects on alcohol consumption and preference were mediated by specific nAChRs. Copyright © 2019 Quiroz, Sotomayor-Zárate, González-Gutierrez, Vizcarra, Moraga, Bermudez, Reyes-Parada, Quintanilla, Lagos, Rivera-Meza and Iturriaga-Vásquez.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectAlcohol dependence
dc.subjectEthanol
dc.subjectnAChR antagonism
dc.subjectUChB rats
dc.subjectVoluntary ethanol drinking
dc.subjectalcohol
dc.subjectbuffer
dc.subjectnicotinic receptor
dc.subjectnicotinic receptor blocking agent
dc.subjectoctanol
dc.subjectufr 2709
dc.subjectunclassified drug
dc.subjectalcohol consumption
dc.subjectalcoholism
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug dose comparison
dc.subjectdrug effect
dc.subjectfluid intake
dc.subjectlocomotion
dc.subjectmale
dc.subjectmotor effect
dc.subjectmotor performance
dc.subjectnonhuman
dc.subjectrat
dc.titleUFR2709, a nicotinic acetylcholine receptor antagonist, decreases ethanol intake in alcohol-preferring rats
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85076903505.pdf
Tamaño:
3.284Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem