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Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls

dc.contributor.authorParra T.
dc.contributor.authorBenites J.
dc.contributor.authorRuiz L.M.
dc.contributor.authorSepulveda B.
dc.contributor.authorSimirgiotis M.
dc.contributor.authorAreche C.
dc.date.accessioned2020-09-02T22:25:22Z
dc.date.available2020-09-02T22:25:22Z
dc.date.issued2015
dc.identifier10.1016/j.bmcl.2015.04.095
dc.identifier.citation25, 14, 2813-2817
dc.identifier.issn0960894X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5755
dc.descriptionSeventeen compounds (2-18) synthetized from the diterpenoid ent-beyer-15-en-18-ol (1) isolated from aerial part of Baccharis tola were tested for their gastroprotective activity on the model of HCl/EtOH-induced gastric lesions in mice. Furthermore cytotoxicity test toward fibroblasts and AGS cells were performed. The results showed that compound 1 (ED<inf>50</inf> = 50 mg/kg), 2, 6 and 13 were the most active regarding gastroprotective activity. Compounds 8-10 and 17-18 showed the lowest cytotoxicity toward fibroblasts and AGS cells. Regarding to mode of gastroprotective action, the effect elicited by 6 (50 mg/kg) was reversed by Indomethacin but not by N-ethylmaleimide, NG-nitro-l-arginine methyl ester or ruthenium red, which suggests that prostaglandins are involved in the mode of gastroprotective action of 6. © 2015 Elsevier Ltd.All rights reserved.
dc.language.isoen
dc.publisherElsevier Ltd
dc.subjectBaccharis tola
dc.subjectDiterpenoids
dc.subjectent-Beyerene
dc.subjectGastric ulcer
dc.subjectSemisynthetic derivatives
dc.subjectditerpenoid
dc.subjectent beyer 15 en 18 ol
dc.subjectent beyer 15 en 18 yl 3 chlorocinnamate
dc.subjectent beyerene derivative
dc.subjectindometacin
dc.subjectlansoprazole
dc.subjectn ethylmaleimide
dc.subjectn(g) nitroarginine methyl ester
dc.subjectprostaglandin derivative
dc.subjectruthenium red
dc.subjectthiol derivative
dc.subjectunclassified drug
dc.subjectabietane derivative
dc.subjectantiulcer agent
dc.subjectindometacin
dc.subjectplant extract
dc.subjectprostaglandin
dc.subjectthiol derivative
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectBaccharis tola
dc.subjectcontrolled study
dc.subjectdrug cytotoxicity
dc.subjectdrug isolation
dc.subjectdrug mechanism
dc.subjectdrug synthesis
dc.subjectfibroblast
dc.subjecthuman
dc.subjecthuman cell
dc.subjectmedicinal plant
dc.subjectmouse
dc.subjectnonhuman
dc.subjectstomach lesion
dc.subjectstomach protection
dc.subjectstomach secretion
dc.subjectstructure activity relation
dc.subjectanimal
dc.subjectBaccharis
dc.subjectcell line
dc.subjectcell survival
dc.subjectchemically induced
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectgastric mucosa
dc.subjectisolation and purification
dc.subjectmetabolism
dc.subjectplant structures
dc.subjectsecretion (process)
dc.subjectstomach juice
dc.subjectstomach ulcer
dc.subjectBaccharis
dc.subjectGossweilerodendron balsamiferum
dc.subjectMus
dc.subjectAnimals
dc.subjectAnti-Ulcer Agents
dc.subjectBaccharis
dc.subjectCell Line
dc.subjectCell Survival
dc.subjectDiterpenes, Abietane
dc.subjectGastric Juice
dc.subjectGastric Mucosa
dc.subjectHumans
dc.subjectIndomethacin
dc.subjectMice
dc.subjectPlant Components, Aerial
dc.subjectPlant Extracts
dc.subjectProstaglandins
dc.subjectStomach Ulcer
dc.subjectSulfhydryl Compounds
dc.titleGastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls
dc.typeArticle


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