Gastroprotective activity of ent-beyerene derivatives in mice: Effects on gastric secretion, endogenous prostaglandins and non-protein sulfhydryls
Autor
Parra T.
Benites J.
Ruiz L.M.
Sepulveda B.
Simirgiotis M.
Areche C.
Resumen
Seventeen compounds (2-18) synthetized from the diterpenoid ent-beyer-15-en-18-ol (1) isolated from aerial part of Baccharis tola were tested for their gastroprotective activity on the model of HCl/EtOH-induced gastric lesions in mice. Furthermore cytotoxicity test toward fibroblasts and AGS cells were performed. The results showed that compound 1 (ED<inf>50</inf> = 50 mg/kg), 2, 6 and 13 were the most active regarding gastroprotective activity. Compounds 8-10 and 17-18 showed the lowest cytotoxicity toward fibroblasts and AGS cells. Regarding to mode of gastroprotective action, the effect elicited by 6 (50 mg/kg) was reversed by Indomethacin but not by N-ethylmaleimide, NG-nitro-l-arginine methyl ester or ruthenium red, which suggests that prostaglandins are involved in the mode of gastroprotective action of 6. © 2015 Elsevier Ltd.All rights reserved.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Seco-taondiol, an unusual meroterpenoid from the Chilean seaweed Stypopodium flabelliforme and its gastroprotective effect in mouse model (2020)
Areche C.; Benites J.; Cornejo A.; Ruiz L.M.; García-Beltrán O.; Simirgiotis M.J.; Sepúlveda B. (MDPI AG, 2015) -
Article
Synthesis of new hydrated geranylphenols and in vitro antifungal activity against botrytis cinerea (2020)
Soto M.; Espinoza L.; Chávez M.I.; Díaz K.; Olea A.F.; Taborga L. (MDPI AG, 2016) -
Review
Nootropic and Anti-Alzheimer’s Actions of Medicinal Plants: Molecular Insight into Therapeutic Potential to Alleviate Alzheimer’s Neuropathology (2020)
Uddin M.S.; Al Mamun A.; Kabir M.T.; Jakaria M.; Mathew B.; Barreto G.E.; Ashraf G.M. (Humana Press Inc., 2019)