Could Perinatal Asphyxia Induce a Synaptopathy? New Highlights from an Experimental Model
Autor
Herrera M.I.
Otero-Losada M.
Udovin L.D.
Kusnier C.
Kölliker-Frers R.
De Souza W.
Capani F.
Resumen
Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia. Nearly 25% of the newborns who survive perinatal asphyxia develop neurological disorders such as cerebral palsy and certain neurodevelopmental and learning disabilities where synaptic connectivity disturbances may be involved. Accordingly, here we review and discuss the association of possible synaptic dysfunction with perinatal asphyxia on the basis of updated evidence from an experimental model. © 2017 Mariá Inés Herrera et al.
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Corrigendum: Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats (Front. Behav. Neurosci., (2022), 16, 953157, 10.3389/fnbeh.2022.953157) (2024)
Herrera, Maria I.; Udovin, Lucas D.; Kobiec, Tamara; Toro-Urrego, Nicolas; Kusnier, Carlos F.; Kölliker-Frers, Rodolfo A.; Luaces, Juan P.; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2022)In the original article, there was an error in affiliations #3 and #4. Instead of “1. Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Pontificia Universidad Católica Argentina, Buenos ... -
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Palmitoylethanolamide attenuates neurodevelopmental delay and early hippocampal damage following perinatal asphyxia in rats (2024)
Herrera, Maria I.; Udovin, Lucas D.; Kobiec, Tamara; Toro-Urrego, Nicolas; Kusnier, Carlos F.; Kölliker-Frers, Rodolfo A.; Luaces, Juan P.; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2022)Impaired gas exchange close to labor causes perinatal asphyxia (PA), a neurodevelopmental impairment factor. Palmitoylethanolamide (PEA) proved neuroprotective in experimental brain injury and neurodegeneration models. ... -
Article
Synaptoprotection in Perinatal Asphyxia: An Experimental Approach (2020)
Herrera, María Inés; Kobiec, Tamara; Kölliker-Frers, Rodolfo Alberto; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2020-09-23)Perinatal asphyxia (PA) is an obstetric complication occurring when the oxygen supply to the newborn is temporally interrupted. This health problem is associated with high morbimortality in term and preterm neonates. It ...