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Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis

dc.contributor.authorGonzález-Giraldo Y.
dc.contributor.authorBarreto G.E.
dc.contributor.authorFava C.
dc.contributor.authorForero D.A.
dc.date.accessioned2020-09-02T22:19:22Z
dc.date.available2020-09-02T22:19:22Z
dc.date.issued2016
dc.identifier10.1016/j.jstrokecerebrovasdis.2016.05.020
dc.identifier.citation25, 9, 2284-2289
dc.identifier.issn10523057
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4721
dc.descriptionBackground Ischemic stroke (IS) is a leading cause of death and disability worldwide. As genetic heritability for IS is estimated at about 35%-40%, the identification of genetic variants associated with IS risk is of great importance. The main objective of this study was to carry out a meta-analysis for polymorphisms in CRP, EPHX2, FGA, and NOTCH3 genes and the risk for IS. Methods Literature search for 6 candidate polymorphisms and IS was conducted using HuGE Navigator, PubMed, and Google Scholar databases. Meta-Analyst program was used to calculate pooled odds ratios (ORs) with a random effects model. Results Twenty-five published studies for 6 candidate polymorphisms were included: CRP-rs1800947 (5 studies), CRP-rs1205 (3 studies), EPHX2-rs751141 (5 studies), FGA-rs6050 (6 studies), NOTCH3-rs3815188 (3 studies), and NOTCH3-rs1043994 (3 studies), for a total number of 7,825 IS cases and 56,532 control subjects. We did not find significant pooled ORs (P values > .05) for any of the genetic variants evaluated in this work. Conclusions Our meta-analysis results did not show significant associations between these 6 polymorphisms in 4 candidate genes and IS, despite the functional role of some of these single nucleotide polymorphisms (e.g., rs6050 in FGA gene). Future studies are needed to identify additional main genetic risk factors for IS in different populations. © 2016 National Stroke Association
dc.language.isoen
dc.publisherW.B. Saunders
dc.subjectCandidate gene
dc.subjectgenetic factors
dc.subjectischemic stroke
dc.subjectmeta-analysis
dc.subjectpolymorphism
dc.subjectrisk factor
dc.subjectC reactive protein
dc.subjectepoxide hydrolase 2
dc.subjectfibrinogen alpha chain
dc.subjectNotch3 receptor
dc.subjectprotein
dc.subjectunclassified drug
dc.subjectC reactive protein
dc.subjectEPHX2 protein, human
dc.subjectepoxide hydrolase
dc.subjectNotch3 receptor
dc.subjectprostaglandin A
dc.subjectArticle
dc.subjectbrain ischemia
dc.subjectgene frequency
dc.subjectgenetic association
dc.subjectgenetic risk
dc.subjectgenetic variability
dc.subjecthuman
dc.subjectmeta analysis
dc.subjectpriority journal
dc.subjectrestriction fragment length polymorphism
dc.subjectsingle nucleotide polymorphism
dc.subjectbibliographic database
dc.subjectbrain ischemia
dc.subjectcomplication
dc.subjectgenetic predisposition
dc.subjectgenetic variation
dc.subjectgenetics
dc.subjectstatistics and numerical data
dc.subjectStroke
dc.subjectBrain Ischemia
dc.subjectC-Reactive Protein
dc.subjectDatabases, Bibliographic
dc.subjectEpoxide Hydrolases
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Variation
dc.subjectHumans
dc.subjectProstaglandins A
dc.subjectReceptor, Notch3
dc.subjectStroke
dc.titleIschemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis
dc.typeArticle


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