Telomere length in Parkinson's disease: A meta-analysis
Autor
Forero D.A.
González-Giraldo Y.
López-Quintero C.
Castro-Vega L.J.
Barreto G.E.
Perry G.
Resumen
Parkinson's disease (PD) is a common and severe movement disorder. Differences in telomere length (TL) have been reported as possible risk factors for several neuropsychiatric disorders, including PD. Results from published studies for TL in PD are inconsistent, highlighting the need for a meta-analysis. In the current work, a meta-analysis of published studies for TL in PD was carried out. PubMed, Web of Science and Google Scholar databases were used to identify relevant articles that reported TL in groups of PD patients and controls. A random-effects model was used for meta-analytical procedures. The meta-analysis included eight primary studies, derived from populations of European and Asian descent, and did not show a significant difference in TL between 956 PD patients and 1284 controls (p value: 0.246). Our results show that there is no consistent evidence of shorter telomeres in PD patients and suggest the importance of future studies on TL and PD that analyze other populations and also include assessment of TL from different brain regions. © 2016 Elsevier Inc.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Meta-analysis of Telomere Length in Alzheimer's Disease (2020)
Forero D.A.; González-Giraldo Y.; López-Quintero C.; Castro-Vega L.J.; Barreto G.E.; Perry G. (Oxford University Press, 2016) -
Article
Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis (2020)
González-Giraldo Y.; Barreto G.E.; Fava C.; Forero D.A. (W.B. Saunders, 2016) -
Article
Plasma microRNAs as biomarkers for Lamin A/C-related dilated cardiomyopathy (2020)
Toro R.; Blasco-Turrión S.; Morales-Ponce F.J.; Gonzalez P.; Martínez-Camblor P.; López-Granados A.; Brugada R.; Campuzano O.; Pérez-Serra A.; Rosa Longobardo F.; ... (Springer Verlag, 2018)