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N-alkylimidazolium Salts Functionalized with p-Coumaric and Cinnamic Acid: A study of their antimicrobial and antibiofilm effects

dc.contributor.authorForero-Doria O.
dc.contributor.authorAraya-Maturana R.
dc.contributor.authorBarrientos-Retamal A.
dc.contributor.authorMorales-Quintana L.
dc.contributor.authorGuzmán L.
dc.date.accessioned2020-09-02T22:17:57Z
dc.date.available2020-09-02T22:17:57Z
dc.date.issued2019
dc.identifier10.3390/molecules24193484
dc.identifier.citation24, 19, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4513
dc.descriptionThe bacterial resistance to antibiotics has compromised the therapies used for bacterial infections. Nowadays, many strategies are being carried out to address this problem. Among them, the use of natural compounds like cinnamic and p-coumaric acids stands out. Nevertheless, their utilization is limited because of their unfavorable physicochemical properties. Due to the lack of new therapeutic alternatives for bacterial infections, novel strategies have emerged, such as the use of ionic liquids; given that they can show a broad spectrum of antibacterial activity, this is why we herein report the antibacterial and antibiofilm activity of a series of N-alkylimidazolium salts functionalized with p-coumaric and cinnamic acids. The results from this study showed better antibacterial activity against Gram-positive bacteria, with a predominance of the salts derived from coumaric acid and a correlation with the chain length. Additionally, a lower efficacy was observed in the inhibition of biofilm formation, highlighting the antibiofilm activity against Staphylococcus aureus, which decreased the production of the biofilm by 52% over the control. In conclusion, we suggest that the salts derived from p-coumaric acid are good alternatives as antibacterial compounds. Meanwhile, the salt derived from cinnamic acid could be a good alternative as an antibiofilm compound. © 2019 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAntibiofilm effects
dc.subjectAntimicrobial agents
dc.subjectCinnamoylimidazole salts
dc.subjectIonic liquids
dc.subjectantiinfective agent
dc.subjectcinnamic acid
dc.subjectcinnamic acid derivative
dc.subjectimidazole
dc.subjectimidazole derivative
dc.subjectionic liquid
dc.subjectpropionic acid derivative
dc.subjecttrans-3-(4'-hydroxyphenyl)-2-propenoic acid
dc.subjectbiofilm
dc.subjectchemistry
dc.subjectconformation
dc.subjectdrug effect
dc.subjectmicrobial sensitivity test
dc.subjectmolecular dynamics
dc.subjectstructure activity relation
dc.subjectAnti-Infective Agents
dc.subjectBiofilms
dc.subjectCinnamates
dc.subjectImidazoles
dc.subjectIonic Liquids
dc.subjectMicrobial Sensitivity Tests
dc.subjectMolecular Conformation
dc.subjectMolecular Dynamics Simulation
dc.subjectPropionates
dc.subjectStructure-Activity Relationship
dc.titleN-alkylimidazolium Salts Functionalized with p-Coumaric and Cinnamic Acid: A study of their antimicrobial and antibiofilm effects
dc.typeArticle


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