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Telomere length in Parkinson's disease: A meta-analysis

dc.contributor.authorForero D.A.
dc.contributor.authorGonzález-Giraldo Y.
dc.contributor.authorLópez-Quintero C.
dc.contributor.authorCastro-Vega L.J.
dc.contributor.authorBarreto G.E.
dc.contributor.authorPerry G.
dc.date.accessioned2020-09-02T22:17:56Z
dc.date.available2020-09-02T22:17:56Z
dc.date.issued2016
dc.identifier10.1016/j.exger.2016.01.002
dc.identifier.citation75, , 53-55
dc.identifier.issn05315565
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4512
dc.descriptionParkinson's disease (PD) is a common and severe movement disorder. Differences in telomere length (TL) have been reported as possible risk factors for several neuropsychiatric disorders, including PD. Results from published studies for TL in PD are inconsistent, highlighting the need for a meta-analysis. In the current work, a meta-analysis of published studies for TL in PD was carried out. PubMed, Web of Science and Google Scholar databases were used to identify relevant articles that reported TL in groups of PD patients and controls. A random-effects model was used for meta-analytical procedures. The meta-analysis included eight primary studies, derived from populations of European and Asian descent, and did not show a significant difference in TL between 956 PD patients and 1284 controls (p value: 0.246). Our results show that there is no consistent evidence of shorter telomeres in PD patients and suggest the importance of future studies on TL and PD that analyze other populations and also include assessment of TL from different brain regions. © 2016 Elsevier Inc.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectEpigenomics
dc.subjectMeta-analysis
dc.subjectMovement disorders
dc.subjectParkinson's disease
dc.subjectTelomeres
dc.subjectgenomic DNA
dc.subjectArticle
dc.subjectAsian
dc.subjectbrain region
dc.subjectchromosomal parameters
dc.subjectdisease association
dc.subjectepigenetics
dc.subjectEuropean
dc.subjecthuman
dc.subjectParkinson disease
dc.subjectpolymerase chain reaction
dc.subjectpriority journal
dc.subjecttelomere length
dc.subjectcase control study
dc.subjectgenetics
dc.subjectmeta analysis
dc.subjectParkinson disease
dc.subjectpathology
dc.subjectrisk factor
dc.subjecttelomere
dc.subjecttelomere shortening
dc.subjectCase-Control Studies
dc.subjectHumans
dc.subjectParkinson Disease
dc.subjectRisk Factors
dc.subjectTelomere
dc.subjectTelomere Shortening
dc.titleTelomere length in Parkinson's disease: A meta-analysis
dc.typeArticle


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