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Meta-analysis of Telomere Length in Alzheimer's Disease

dc.contributor.authorForero D.A.
dc.contributor.authorGonzález-Giraldo Y.
dc.contributor.authorLópez-Quintero C.
dc.contributor.authorCastro-Vega L.J.
dc.contributor.authorBarreto G.E.
dc.contributor.authorPerry G.
dc.date.accessioned2020-09-02T22:17:56Z
dc.date.available2020-09-02T22:17:56Z
dc.date.issued2016
dc.identifier10.1093/gerona/glw053
dc.identifier.citation71, 8, 1069-1073
dc.identifier.issn10795006
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4511
dc.descriptionBackground: Alzheimer's disease (AD) is a common and severe neurodegenerative disorder. Human telomeres are fundamental for the maintenance of genomic stability and play prominent roles in both cellular senescence and organismal aging. Regulation of telomere length (TL) is the result of the complex interplay between environmental and genetic factors. Alterations in TL are increasingly being studied as a possible risk factor for AD, and published studies on TL in AD show discrepant results, highlighting the need for a meta-analysis. Methods: In the current study, we carried out a meta-analysis of published studies of TL in AD patients and healthy controls. PubMed, Web of Science and Google Scholar databases (from inception to September 2015) were used to identify relevant articles reporting TL in humans with AD, from which we retrieved data such as sample size, experimental methods, and mean TL for cases and controls. A random-effects model was used for meta-analytical procedures. Results: The meta-analysis included 13 primary studies and demonstrated a significant difference in TL between 860 AD patients and 2,022 controls, with a standardized mean difference of -0.984 (confidence interval: -1.433 to -0.535; p value: <.001). Conclusions: Our results show a consistent evidence of shorter telomeres in AD patients and highlight the importance of the analysis of epigenomic markers associated with neurodegeneration and with the risk for common and severe neurological diseases, such as AD. © 2016 The Author. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
dc.language.isoen
dc.publisherOxford University Press
dc.subjectAlzheimer's disease
dc.subjectDementia
dc.subjectEpigenomics
dc.subjectMeta-analysis
dc.subjectTelomeres
dc.subjectaging
dc.subjectAlzheimer disease
dc.subjectevidence based medicine
dc.subjectgenetics
dc.subjecthuman
dc.subjectmeta analysis
dc.subjectrisk factor
dc.subjecttelomere
dc.subjecttelomere shortening
dc.subjectAging
dc.subjectAlzheimer Disease
dc.subjectEvidence-Based Medicine
dc.subjectHumans
dc.subjectRisk Factors
dc.subjectTelomere
dc.subjectTelomere Shortening
dc.titleMeta-analysis of Telomere Length in Alzheimer's Disease
dc.typeArticle


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