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Surveillance after cardiac arrest in patients with Brugada syndrome without an implantable defibrillator: An alarm effect of the previous syncope

dc.contributor.authorCalvo D.
dc.contributor.authorFlórez J.P.
dc.contributor.authorValverde I.
dc.contributor.authorRubín J.
dc.contributor.authorPérez D.
dc.contributor.authorVasserot M.G.
dc.contributor.authorRodríguez-Reguero J.
dc.contributor.authorAvanzas P.
dc.contributor.authorDe La Hera J.M.
dc.contributor.authorGómez J.
dc.contributor.authorCoto E.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorMorís C.
dc.date.accessioned2020-09-02T22:14:14Z
dc.date.available2020-09-02T22:14:14Z
dc.date.issued2016
dc.identifier10.1016/j.ijcard.2016.05.018
dc.identifier.citation218, , 69-74
dc.identifier.issn01675273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/3926
dc.descriptionBackground Debate regarding the prognosis of asymptomatic patients with Brugada syndrome (BrS) is possibly affected by the selection bias of survivors of sudden cardiac arrest (SCA). We aimed to determine variables influencing surveillance after SCA. Methods We analyzed a BrS cohort of 145 patients belonging to 37 families. We compared the clinical data and circumstances surrounding SCA (i.e., place of occurrence and people accompanying the subject) in 10 patients who survived an episode of SCA (Group A) vs. 27 deceased relatives (first or second degree) who suffered sudden cardiac death (SCD; Group B). Information concerning Group B was agreed upon by at least 3 relatives. A sub-analysis was performed considering families carrying a mutation in SCN5A (Group B-Mutant). Results Syncope was unique in predicting SCA in the BrS cohort. Comparing Groups A vs. B, there were no differences in the mean age at time of SCA/SCD (46.2 [SD 17.1] vs. 39.9 [SD 14.5] years; p = 0.271), gender (male 60% vs. 74.1%; p = 0.442), prior cardiomyopathy (0%), administration of cardiovascular treatments (anti-hypertensive and lipid-lowering drugs; 20% vs. 14.8%; p = 0.653) or conventional cardiovascular risk factors. Environmental circumstances surrounding the SCA/SCD were not significantly different between groups. Prior syncope was more frequent in Group A (80% vs. 3.7%; p < 0.001) and unique in predicting surveillance (p < 0.001). Group B-Mutant displayed equivalent data. Conclusions A previous syncope, as an alarm symptom, might contribute to better surveillance of SCA compared with subjects with SCA as the debut of BrS. The latter might behave as a factor of selection bias. © 2016 Elsevier Ireland Ltd. All rights reserved.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectBrugada syndrome
dc.subjectSudden cardiac death
dc.subjectSyncope
dc.subjectadult
dc.subjectage
dc.subjectArticle
dc.subjectBrugada syndrome
dc.subjectcardiomyopathy
dc.subjectcardiovascular risk
dc.subjectcontrolled study
dc.subjectdrug use
dc.subjectfaintness
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpriority journal
dc.subjectrisk factor
dc.subjectselection bias
dc.subjectsex difference
dc.subjectsudden cardiac death
dc.subjectalarm monitor
dc.subjectBrugada syndrome
dc.subjectheart arrest
dc.subjectimplantable cardioverter defibrillator
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectpathophysiology
dc.subjectretrospective study
dc.subjectsurvival rate
dc.subjectSyncope
dc.subjecttrends
dc.subjectAdult
dc.subjectBrugada Syndrome
dc.subjectClinical Alarms
dc.subjectDefibrillators, Implantable
dc.subjectFemale
dc.subjectHeart Arrest
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.subjectSyncope
dc.titleSurveillance after cardiac arrest in patients with Brugada syndrome without an implantable defibrillator: An alarm effect of the previous syncope
dc.typeArticle


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