Surveillance after cardiac arrest in patients with Brugada syndrome without an implantable defibrillator: An alarm effect of the previous syncope
Autor
Calvo D.
Flórez J.P.
Valverde I.
Rubín J.
Pérez D.
Vasserot M.G.
Rodríguez-Reguero J.
Avanzas P.
De La Hera J.M.
Gómez J.
Coto E.
Martínez-Camblor P.
Morís C.
Resumen
Background Debate regarding the prognosis of asymptomatic patients with Brugada syndrome (BrS) is possibly affected by the selection bias of survivors of sudden cardiac arrest (SCA). We aimed to determine variables influencing surveillance after SCA. Methods We analyzed a BrS cohort of 145 patients belonging to 37 families. We compared the clinical data and circumstances surrounding SCA (i.e., place of occurrence and people accompanying the subject) in 10 patients who survived an episode of SCA (Group A) vs. 27 deceased relatives (first or second degree) who suffered sudden cardiac death (SCD; Group B). Information concerning Group B was agreed upon by at least 3 relatives. A sub-analysis was performed considering families carrying a mutation in SCN5A (Group B-Mutant). Results Syncope was unique in predicting SCA in the BrS cohort. Comparing Groups A vs. B, there were no differences in the mean age at time of SCA/SCD (46.2 [SD 17.1] vs. 39.9 [SD 14.5] years; p = 0.271), gender (male 60% vs. 74.1%; p = 0.442), prior cardiomyopathy (0%), administration of cardiovascular treatments (anti-hypertensive and lipid-lowering drugs; 20% vs. 14.8%; p = 0.653) or conventional cardiovascular risk factors. Environmental circumstances surrounding the SCA/SCD were not significantly different between groups. Prior syncope was more frequent in Group A (80% vs. 3.7%; p < 0.001) and unique in predicting surveillance (p < 0.001). Group B-Mutant displayed equivalent data. Conclusions A previous syncope, as an alarm symptom, might contribute to better surveillance of SCA compared with subjects with SCA as the debut of BrS. The latter might behave as a factor of selection bias. © 2016 Elsevier Ireland Ltd. All rights reserved.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
The adverse prognostic effect of tumor budding on the evolution of cutaneous head and neck squamous cell carcinoma (2020)
Gonzalez-Guerrero M.; Martínez-Camblor P.; Vivanco B.; Fernández-Vega I.; Munguía-Calzada P.; Gonzalez-Gutierrez M.P.; Rodrigo J.P.; Galache C.; Santos-Juanes J. (Mosby Inc., 2017) -
Article
Improvement of mineral and bone metabolism markers is associated with better survival in haemodialysis patients: The COSMOS study (2020)
Fernandez-Martin J.L.; Martinez-Camblor P.; Dionisi M.P.; Floege J.; Ketteler M.; London G.; Locatelli F.; Gorriz J.L.; Rutkowski B.; Ferreira A.; ... (Oxford University Press, 2015) -
Article
Serum phosphate optimal timing and range associated with patients survival in haemodialysis: The COSMOS study (2020)
Fernández-Martín J.L.; Dusso A.; Martínez-Camblor P.; Dionisi M.P.; Floege J.; Ketteler M.; London G.; Locatelli F.; Górriz J.L.; Rutkowski B.; ... (Oxford University Press, 2019)