Listar Investigación y Desarrollo por autor "Olea, Andrés F."
Mostrando ítems 1-7 de 7
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Article
Antimicrobial Activity of Drimanic Sesquiterpene Compounds from Drimys winteri against Multiresistant Microorganisms (2024)
Montenegro, Iván; Pazmiño, Rolando; Araque, Ileana; Madrid, Alejandro; Besoain, Ximena; Werner, Enrique; Espinoza-Catalán, Luis; Olea, Andrés F.; Parra, Claudio; Navarrete Molina, Valentina; ... (Multidisciplinary Digital Publishing Institute (MDPI), 2024)In this work, a group of ten sesquiterpene drimanes, including polygodial (1), isopolygodial (2), and drimenol (3) obtained from the bark of Drimys winteri F. and seven synthetic derivatives, were tested in vitro against ... -
Article
Ethanolic Extract from Fruits of Pintoa chilensis, a Chilean Extremophile Plant. Assessment of Antioxidant Activity and In Vitro Cytotoxicity (2024)
Arrieche, Dioni; Olea, Andrés F.; Jara-Gutiérrez, Carlos; Villena, Joan; Pardo-Baeza, Javier; García-Davis, Sara; Viteri, Rafael; Taborga, Lautaro; Carrasco, Héctor (Multidisciplinary Digital Publishing Institute (MDPI), 2024)Pintoa chilensis is a shrub with yellow flowers that reach up to two meters high, endemic of the Atacama Region in Chile. This species grows under special environmental conditions such as low altitude, arid areas, and ... -
Article
New Brassinosteroid Analogs with 23,24-Dinorcholan Side Chain, and Benzoate Function at C-22: Synthesis, Assessment of Bioactivity on Plant Growth, and Molecular Docking Study (2024)
Aitken, Vanessa; Diaz, Katy; Soto, Mauricio; Olea, Andrés F.; Cuellar, Mauricio A.; Nuñez, Maria; Espinoza-Catalán, Luis (Multidisciplinary Digital Publishing Institute (MDPI), 2024)The synthesis and biological evaluation of brassinosteroids (BRs) analogs with chemical modification in the side alkyl chain is a matter of current interest. Recently, a series of BR analogs with phenyl or benzoate groups ... -
Article
Secondary Metabolites Isolated from Chilean Marine Algae: A Review (2022)
Arrieche, Dioni; Carrasco, Héctor; Olea, Andrés F.; Espinoza, Luis; San-Martín, Aurelio; Taborga, Lautaro (MDPI, 2022-05)Chile is in the extreme southwestern part of America, and it has an extreme length, of approximately 4300 km that increases to 8000 km considering the Chilean Antarctic Territory. Despite the large extent of its coastal ... -
Article
Study of Cannabis Oils Obtained from Three Varieties of C. sativa and by Two Different Extraction Methods: Phytochemical Characterization and Biological Activities (2024)
Pino, Sebastián; Espinoza, Luis; Jara-Gutiérrez, Carlos; Villena, Joan; Olea, Andrés F.; Díaz, Katy (MDPI, 2023)Currently, much effort is being placed into obtaining extracts and/or essential oils from Cannabis sativa L. for specific therapeutic purposes or pharmacological compositions. These potential applications depend mainly on ... -
Article
Synthesis of Four Steroidal Carbamates with Antitumor Activity against Mouse Colon Carcinoma CT26WT Cells: In Vitro and In Silico Evidence (2024)
Pacheco, Daylin Fernández; Alonso, Dayana; Ceballos, Leonardo González; Castro, Armando Zaldo; Brown Roldán, Sheila; García Díaz, Mairelys; Villa Testa, Anabel; Wagner, Sarah Fuentes; Piloto-Ferrer, Janet; García, Yamilet Coll; ... (MDPI, 2022)Colorectal cancer (CRC) is one of the most lethal cancers worldwide. If detected on time, surgery can expand life expectations of patients up to five more years. However, if metastasis has grown deliberately, the use of ... -
Article
The Synthesis of Novel aza-Steroids and α, β-Unsaturated-Cyanoketone from Diosgenin (2024)
Mesa, Dayana; Augusto, Yarelys E.; Hernández, Giselle; Figueroa-Macías, Juan P.; Coll, Francisco; Olea, Andrés F.; Núñez, María; Campo, Hernán Astudillo; Coll, Yamilet; Espinoza, Luis (Multidisciplinary Digital Publishing Institute (MDPI), 2023)Recent studies have demonstrated the antiproliferative and cytotoxic effects of aza-steroids and steroidal sapogenins on human cancer cell lines. The scientific community has shown a growing interest in these compounds as ...