Listar Investigación y Desarrollo por autor "Castro-Santos, Patricia"
Mostrando ítems 1-7 de 7
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Article
Acquisition of new migratory properties by highly differentiated cd4+cd28null t lymphocytes in rheumatoid arthritis disease (2021)
Rioseras, Beatriz; Moro-García, Marco Antonio; García-Torre, Alejandra; Bueno-García, Eva; López-Martínez, Rocio; Iglesias-Escudero, María; Díaz-Peña, Roberto; Castro-Santos, Patricia; Arias-Guillén, Miguel; Alonso-Arias, R. (MDPI AG, 2021-07)Expanded CD4+CD28null T lymphocytes are found in the tissues and peripheral blood of patients with many autoimmune diseases, such as rheumatoid arthritis (RA). These highly differentiated cells present potent inflammatory ... -
Article
Advances of Genomic Medicine in Psoriatic Arthritis (2022)
Laborde, Carlos M.; Larzabal, Leyre; González-Cantero, Álvaro; Castro-Santos, Patricia; Díaz-Peña, Roberto (MDPI, 2022-01)Psoriatic arthritis (PsA) is a common type of inflammatory arthritis found in up to 40% of patients with psoriasis. Although early diagnosis is important for reducing the risk of irreversible structural damage, there are ... -
Article
Contribution of multiplex immunoassays to rheumatoid arthritis management: From biomarker discovery to personalized medicine (2020)
Laborde, Carlos M.; Castro-Santos, Patricia; Díaz-Peña, Roberto (MDPI AG, 2020-10-30)Rheumatoid arthritis (RA) is a multifactorial, inflammatory and progressive autoimmune disease that affects approximately 1% of the population worldwide. RA primarily involves the joints and causes local inflammation and ... -
Article
HLA-DRB1*07:01 and *08:02 alleles confer a protective effect against ACPA-positive rheumatoid arthritis in a latin american admixed population (2021)
Castro-Santos, Patricia; Olloquequi, Jordi; Verdugo, Ricardo A.; Gutiérrez, Miguel A.; Pinochet, Carmen; Quiñones, Luis Abel; Díaz-Peña, Roberto (MDPI AG, 2020-12-14)HLA-DRB1 shared epitope (SE) alleles are important genetic contributors for the risk of developing anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis (RA), particularly in Caucasians. We aimed to ... -
Article
Latin american genes: The great forgotten in rheumatoid arthritis (2020)
Díaz-Peña, Roberto; Quiñones, Luis Abel; Castro-Santos, Patricia; Duran, Josefina; Lucía, Alejandro M. (MDPI AG, 2020-10-26)The successful implementation of personalized medicine will rely on the integration of information obtained at the level of populations with the specific biological, genetic, and clinical characteristics of an individual. ... -
Article
Pharmacogenetic Variation and Its Clinical Relevance in a Latin American Rural Population (2024)
Olloquequi, Jordi; Castro-Santos, Patricia; Díaz-Peña, Roberto (MDPI, 2022)Latin-American populations have been largely underrepresented in genomic studies of drug response and disease susceptibility. In this paper, we present a genome-wide Chilean dataset from Talca based on the Illumina Global ... -
Article
The genetics of spondyloarthritis (2020)
Díaz-Peña, Roberto; Castro-Santos, Patricia; Duran, Josefina; Santiago, Catalina; Lucía, Alejandro M. (MDPI AG, 2020-10-02)The term spondyloarthritis (SpA) encompasses a group of chronic inflammatory diseases with common features in terms of clinical presentation and genetic predisposition. SpA is characterized by inflammation of the spine and ...