Acquisition of new migratory properties by highly differentiated cd4+cd28null t lymphocytes in rheumatoid arthritis disease
Autor
Rioseras, Beatriz
Moro-García, Marco Antonio
García-Torre, Alejandra
Bueno-García, Eva
López-Martínez, Rocio
Iglesias-Escudero, María
Díaz-Peña, Roberto
Castro-Santos, Patricia
Arias-Guillén, Miguel
Alonso-Arias, R.
Resumen
Expanded CD4+CD28null T lymphocytes are found in the tissues and peripheral blood of patients with many autoimmune diseases, such as rheumatoid arthritis (RA). These highly differentiated cells present potent inflammatory activity and capability to induce tissue destruction, which has been suggested to predispose to the development of more aggressive disease. In fact, preferential migration to inflammatory sites has been proposed to be a contributing factor in the progression of autoimmune and cardiovascular diseases frequently found in these patients. The functional activity of CD4+CD28null T lymphocytes is largely dependent on interleukin 15 (IL-15), and this cytokine may also act as a selective attractor of these cells to local inflammatory infiltrates in damaged tissues. We have analysed, in RA patients, the migratory properties and transcriptional motility profile of CD4+CD28null T lymphocytes compared to their counterparts CD28+ T lymphocytes and the enhancing role of IL-15. Identification of the pathways involved in this process will allow us to design strategies directed to block effector functions that CD4+CD28null T lymphocytes have in the target tissue, which may represent therapeutic approaches in this immune disorder.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
HLA-DRB1*07:01 and *08:02 alleles confer a protective effect against ACPA-positive rheumatoid arthritis in a latin american admixed population (2021)
Castro-Santos, Patricia; Olloquequi, Jordi; Verdugo, Ricardo A.; Gutiérrez, Miguel A.; Pinochet, Carmen; Quiñones, Luis Abel; Díaz-Peña, Roberto (MDPI AG, 2020-12-14)HLA-DRB1 shared epitope (SE) alleles are important genetic contributors for the risk of developing anti-citrullinated protein antibodies (ACPA)-positive rheumatoid arthritis (RA), particularly in Caucasians. We aimed to ... -
Article
Latin american genes: The great forgotten in rheumatoid arthritis (2020)
Díaz-Peña, Roberto; Quiñones, Luis Abel; Castro-Santos, Patricia; Duran, Josefina; Lucía, Alejandro M. (MDPI AG, 2020-10-26)The successful implementation of personalized medicine will rely on the integration of information obtained at the level of populations with the specific biological, genetic, and clinical characteristics of an individual. ... -
Article
Contribution of multiplex immunoassays to rheumatoid arthritis management: From biomarker discovery to personalized medicine (2020)
Laborde, Carlos M.; Castro-Santos, Patricia; Díaz-Peña, Roberto (MDPI AG, 2020-10-30)Rheumatoid arthritis (RA) is a multifactorial, inflammatory and progressive autoimmune disease that affects approximately 1% of the population worldwide. RA primarily involves the joints and causes local inflammation and ...