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Exploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chile

dc.contributor.authorReyes, María Elena
dc.contributor.authorZanella, Louise
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorBuchegger, Kurt
dc.contributor.authorMora-Lagos, Bárbara
dc.contributor.authorGuzmán, Pablo
dc.contributor.authorGarcía, Patricia
dc.contributor.authorRoa, Juan C.
dc.contributor.authorIli, Carmen Gloria
dc.contributor.authorBrebi, Priscilla
dc.date.accessioned2024-04-18T07:32:48Z
dc.date.available2024-04-18T07:32:48Z
dc.date.issued2023
dc.identifier10.3390/ijms241411276
dc.identifier.issn16616596
dc.identifier.urihttps://hdl.handle.net/20.500.12728/11210
dc.description.abstractThe Epstein–Barr virus (EBV) has been associated with gastric cancer (GC), one of the deadliest malignancies in Chile and the world. Little is known about Chilean EBV strains. This study aims to investigate the frequency and genetic diversity of EBV in GC in patients in southern Chile. To evaluate the prevalence of EBV in GC patients from the Chilean population, we studied 54 GC samples using the gold standard detection method of EBV-encoded small RNA (EBER). The EBV-positive samples were subjected to amplification and sequencing of the Epstein–Barr virus nuclear protein 3A (EBNA3A) gene to evaluate the genetic diversity of EBV strains circulating in southern Chile. In total, 22.2% of the GC samples were EBV-positive and significantly associated with diffuse-type histology (p = 0.003). Phylogenetic analyses identified EBV-1 and EBV-2 in the GC samples, showing genetic diversity among Chilean isolates. This work provides important information for an epidemiological follow-up of the different EBV subtypes that may cause GC in southern Chile. © 2023 by the authors.es_ES
dc.description.sponsorshipDIUAV, (03-2022); DIUFRO, (DI20-0128, DI20-0160); National Funding for Scientific and Technologic Development of Chile; Horizon 2020 Framework Programme, H2020, (825510); Universidad Autónoma de Coahuila, UAdeC; European Research Council, ERC; Comisión Nacional de Investigación Científica y Tecnológica, CONICYT, (21201835); Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT, (1210440, 1221345, 3170826, 3180550, 3210629, 3210687); Universidad de La Frontera, UFRO; Fondo de Fomento al Desarrollo Científico y Tecnológico, FONDEF, (ID21I10027); Instituto Milenio en Inmunología e Inmunoterapia, MIII, (ICN2021_045); Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias, FONDAP, (152220002); Agencia Nacional de Investigación y Desarrollo, ANID, (NCS2021_013)es_ES
dc.language.isoenes_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es_ES
dc.subjectChilees_ES
dc.subjectEBNA3Aes_ES
dc.subjectEpstein–Barr virus (EBV)es_ES
dc.subjectgastric canceres_ES
dc.subjectphylogenyes_ES
dc.titleExploring the Genetic Diversity of Epstein–Barr Virus among Patients with Gastric Cancer in Southern Chilees_ES
dc.typeArticlees_ES


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