The role of B cells in COVID-19 infection and vaccination
Autor
Chen, Shiru
Guan, Fei
Candotti, Fabio
Benlagha, Kamel
Camara, Niels Olsen Saraiva
Herrada, Andres A.
James, Louisa K.
Lei, Jiahui
Miller, Heather
Kubo, Masato
Ning, Qin
Liu, Chaohong
Resumen
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations. Copyright © 2022 Chen, Guan, Candotti, Benlagha, Camara, Herrada, James, Lei, Miller, Kubo, Ning and Liu.
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