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dc.contributor.authorSchwarz, Karla G.
dc.contributor.authorPereyra, Katherin V.
dc.contributor.authorToledo, Camilo
dc.contributor.authorAndrade, David Cristóbal
dc.contributor.authorDíaz, Hugo S.
dc.contributor.authorDíaz-Jara, Esteban
dc.contributor.authorOrtolani, Domiziana
dc.contributor.authorRíos-Gallardo, Angélica P.
dc.contributor.authorArias, Paulina
dc.contributor.authorlas Heras, Alexandra
dc.contributor.authorVera, Ignacio
dc.contributor.authorOrtiz, Fernando C.
dc.date.accessioned2022-01-18T12:28:43Z
dc.date.available2022-01-18T12:28:43Z
dc.date.issued2021-12
dc.identifier10.1186/s40659-021-00365-z
dc.identifier.issn07169760
dc.identifier.urihttps://hdl.handle.net/20.500.12728/9868
dc.description.abstractBackground: Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several studies showed that activation of the renin-angiotensin system (RAS) play a key role in CHF pathophysiology. Interestingly, potassium (K+) supplemented diets showed promising results in normalizing RAS axis and autonomic dysfunction in vascular diseases, lowering cardiovascular risk. Whether subtle increases in dietary K+ consumption may exert similar effects in CHF has not been previously tested. Accordingly, we aimed to evaluate the effects of dietary K+ supplementation on cardiorespiratory alterations in rats with CHF. Methods: Adult male Sprague–Dawley rats underwent volume overload to induce non-ischemic CHF. Animals were randomly allocated to normal chow diet (CHF group) or supplemented K+ diet (CHF+K+ group) for 6 weeks. Cardiac arrhythmogenesis, sympathetic outflow, baroreflex sensitivity, breathing disorders, chemoreflex function, respiratory–cardiovascular coupling and cardiac function were evaluated. Results: Compared to normal chow diet, K+ supplemented diet in CHF significantly reduced arrhythmia incidence (67.8 ± 15.1 vs. 31.0 ± 3.7 events/hour, CHF vs. CHF+K+), decreased cardiac sympathetic tone (ΔHR to propranolol: − 97.4 ± 9.4 vs. − 60.8 ± 8.3 bpm, CHF vs. CHF+K+), restored baroreflex function and attenuated irregular breathing patterns. Additionally, supplementation of the diet with K+ restores normal central respiratory chemoreflex drive and abrogates pathological cardio-respiratory coupling in CHF rats being the outcome an improved cardiac function. Conclusion: Our findings support that dietary K+ supplementation in non-ischemic CHF alleviate cardiorespiratory dysfunction.es_ES
dc.language.isoenes_ES
dc.publisherBioMed Central Ltdes_ES
dc.subjectAutonomic imbalancees_ES
dc.subjectBreathing disorderses_ES
dc.subjectChemoreflex functiones_ES
dc.subjectHeart failurees_ES
dc.subjectPotassium supplemented dietes_ES
dc.titleEffects of enriched-potassium diet on cardiorespiratory outcomes in experimental non-ischemic chronic heart failurees_ES
dc.typeArticlees_ES


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