Interleukin-1 Links Autoimmune and Autoinflammatory Pathophysiology in Mixed-Pattern Psoriasis
MetadataShow full item record
Kölliker Frers, Rodolfo Alberto
Herrera, María Inés
Udovin, Lucas Daniel
Kusnier, Carlos F.
Autoinflammatory and autoimmune diseases are characterized by an oversensitive immune system with loss of the physiological endogenous regulation, involving multifactorial self-reactive pathological mechanisms of mono- or polygenic nature. Failure in regulatory mechanisms triggers a complex network of dynamic relationships between innate and adaptive immunity, leading to coexistent autoinflammatory and autoimmune processes. Sustained exposure to a trigger or a genetic alteration at the level of the receptors of the natural immune system may lead to abnormal activation of the innate immune system, adaptive system activation, loss of self-tolerance, and systemic inflammation. The IL-1 family members critically activate and regulate innate and adaptive immune responses' diversity and plasticity in autoimmune and/or autoinflammatory conditions. The IL-23/IL-17 axis is key in the communication between innate immunity (IL-23-producing myeloid cells) and adaptive immunity (Th17- and IL-17-expressing CD8+ T cells). In psoriasis, these cytokines are decisive to the different clinical presentations, whether as plaque psoriasis (psoriasis vulgaris), generalized pustular psoriasis (pustular psoriasis), or mixed forms. These forms reflect a gradient between autoimmune pathophysiology with predominant adaptive immune response and autoinflammatory pathophysiology with predominant innate immune response.
Showing items related by title, author, creator and subject.
Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease (2021) Kölliker Frers, Rodolfo Alberto; Udovin, Lucas Daniel; Otero-Losada, Matilde; Kobiec, Tamara; Herrera, María Inés; Palacios, Jorge; Razzitte, Gabriela; Capani, Francisco (Hindawi Limited, 2021)The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or ...
ArticleHerrera, María Inés; Kobiec, Tamara; Kölliker-Frers, Rodolfo Alberto; Otero-Losada, Matilde; Capani, Francisco (Frontiers Media S.A., 2020-09-23)Perinatal asphyxia (PA) is an obstetric complication occurring when the oxygen supply to the newborn is temporally interrupted. This health problem is associated with high morbimortality in term and preterm neonates. It ...
ArticleOtero-Losada, Matilde; Kobiec, Tamara; Udovin, Lucas Daniel; Chevalier, Guenson; Quarracino, Cecilia; Menéndez Maissonave, Camila; Bordet, Sofia; Capani, Francisco; Perez-Lloret, Santiago (Frontiers Media S.A., 2020-09-11)