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dc.contributor.authorEspitia-Almeida, Fabián
dc.contributor.authorDíaz-Uribe, Carlos Enrique
dc.contributor.authorVallejo-Lozada, William Andrés
dc.contributor.authorPeña, Orlando
dc.contributor.authorGómez-Camargo, Doris Esther
dc.contributor.authorRomero Bohórquez, Arnold R.
dc.contributor.authorZárate, Ximena P.
dc.contributor.authorSchott V, Eduardo
dc.date.accessioned2021-06-08T05:20:31Z
dc.date.available2021-06-08T05:20:31Z
dc.date.issued2021
dc.identifier10.1007/s11696-021-01702-y
dc.identifier.issn03666352
dc.identifier.urihttps://hdl.handle.net/20.500.12728/8923
dc.description.abstractIn this work, we synthesized the meso-(aryl) porphyrin derivative 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP) and two meso-(aryl) metalloporphyrins, TCPP-Zn(II) and TCPP-Sn(IV), with reaction yields between 33.91 and 80.4%. The photophysical properties were determined, and the in vitro photodynamic properties were evaluated against Leishmania spp in the promastigote stage. The TCPP-Zn(II) reduced the viability of the parasites as shown by the lowest IC50, which is even lower than the reference drug glucantime. In general, our results indicate that the beneficial effect related to the lethal capacity of porphyrins was greater in the presence of light irradiation. Furthermore, the inclusion of a diamagnetic metal such as Zn(II) is essential for the biological properties shown by this type of compounds, as it substantially improves their photodynamic activity. The Jablonsky diagrams were proposed using DFT computations, where the decay channels through the ground and excited states were assessed and the feasible generation of singlet oxygen was established, being TCPP-Zn(II) the one that shows a slightly more exothermic process than TCPP-Sn(IV).es_ES
dc.language.isoenes_ES
dc.publisherSpringer Science and Business Media Deutschland GmbHes_ES
dc.subjectDFTes_ES
dc.subjectLeishmania sppes_ES
dc.subjectPhotodynamic therapyes_ES
dc.subjectPorphyrines_ES
dc.subjectPromastigotees_ES
dc.subjectSinglet oxygenes_ES
dc.titlePhotodynamic effect of 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin and (Zn2+ and Sn4+) derivatives against Leishmania spp in the promastigote stage: experimental and DFT studyes_ES
dc.typeArticlees_ES


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