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dc.contributor.authorAndrade, David Cristóbal
dc.contributor.authorToledo, Camilo
dc.contributor.authorDíaz, Hugo S.
dc.contributor.authorPereyra, Katherin V.
dc.contributor.authorSchwarz, Karla G.
dc.contributor.authorDíaz-Jara, Esteban
dc.contributor.authorMelipillán, Claudia A.
dc.contributor.authorRíos-Gallardo, Angélica P.
dc.contributor.authorUribe-Ojeda, Atenea
dc.contributor.authorAlcayaga, Julio
dc.contributor.authorQuintanilla, Rodrigo A.
dc.contributor.authorIturriaga, R.
dc.date.accessioned2021-06-08T03:37:12Z
dc.date.available2021-06-08T03:37:12Z
dc.date.issued2021-06-01
dc.identifier10.1097/HJH.0000000000002756
dc.identifier.issn14735598
dc.identifier.urihttps://hdl.handle.net/20.500.12728/8906
dc.description.abstractBACKGROUND AND OBJECTIVE: Chronic intermittent hypoxia (CIH), one of the main features of obstructive sleep apnea (OSA), enhances carotid body-mediated chemoreflex and induces hypertension and breathing disorders. The carbamylated form of erythropoietin (cEpo) may have beneficial effects as it retains its antioxidant/anti-inflammatory and neuroprotective profile without increasing red blood cells number. However, no studies have evaluated the potential therapeutic effect of cEpo on CIH-related cardiorespiratory disorders. We aimed to determine whether cEpo normalized the CIH-enhanced carotid body ventilatory chemoreflex, the hypertension and ventilatory disorders in rats. METHODS: Male Sprague-Dawley rats (250 g) were exposed to CIH (5% O2, 12/h, 8 h/day) for 28 days. cEPO (20 μg/kg, i.p) was administrated from day 21 every other day for one more week. Cardiovascular and respiratory function were assessed in freely moving animals. RESULTS: Twenty-one days of CIH increased carotid body-mediated chemoreflex responses as evidenced by a significant increase in the hypoxic ventilatory response (FiO2 10%) and triggered irregular eupneic breathing, active expiration, and produced hypertension. cEpo treatment significantly reduced the carotid body--chemoreflex responses, normalizes breathing patterns and the hypertension in CIH. In addition, cEpo treatment effectively normalized carotid body chemosensory responses evoked by acute hypoxic stimulation in CIH rats. CONCLUSION: Present results strongly support beneficial cardiorespiratory therapeutic effects of cEpo during CIH exposure.es_ES
dc.language.isoenes_ES
dc.publisherNLM (Medline)es_ES
dc.titleCarbamylated form of human erythropoietin normalizes cardiorespiratory disorders triggered by intermittent hypoxia mimicking sleep apnea syndromees_ES
dc.typeArticlees_ES


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