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dc.contributor.authorZanella, Louise
dc.contributor.authorReyes, María Elena
dc.contributor.authorRiquelme, Ismael
dc.contributor.authorAbanto, Michel
dc.contributor.authorLeón, Daniela
dc.contributor.authorViscarra, Tamara
dc.contributor.authorIli, Carmen
dc.contributor.authorBrebi, Priscilla
dc.date.accessioned2021-06-08T03:29:18Z
dc.date.available2021-06-08T03:29:18Z
dc.date.issued2021-06-01
dc.identifier10.3390/cancers13112569
dc.identifier.issn20726694
dc.identifier.urihttps://hdl.handle.net/20.500.12728/8905
dc.description.abstractThe Epstein–Barr virus (EBV) is a globally dispersed pathogen involved in several human cancers of B-cell and non-B-cell origin. EBV has been classified into EBV-1 and EBV-2, which have differences in their transformative ability. EBV-1 can transform B-cells into LCL more efficiently than EBV-2, and EBV-2 preferentially infects T-cell lymphocytes. The EBNA3A oncoprotein is a transcriptional regulator of virus and host cell genes, and is required in order to transform B-cells. EBNA3A has six peptide motifs called nuclear localization signals (NLSs) that ensure nucleocyto-plasmic protein trafficking. The presence of multiple NLSs has been suggested to enhance EBNA3 function or different specificities in different cell types. However, studies about the NLS variability associated with EBV types are scarce. Based on a systematic sequence analysis considering more than a thousand EBNA3A sequences of EBV from different human clinical manifestations and geographic locations, we found differences in NLSs’ nucleotide structures among EBV types. Compared with the EBNA3A EBV-1, EBNA3A EBV-2 has two of the six NLSs altered, and these mutations were possibly acquired by recombination. These genetic patterns in the NLSs associated with EBV-1 and EBV-2 provide new information about the traits of EBNA3A in EBV biology.es_ES
dc.language.isoenes_ES
dc.publisherMDPI AGes_ES
dc.subjectEBV classificationes_ES
dc.subjectEBV nuclear antigen EBNA 3A (EBNA3A)es_ES
dc.subjectEpstein–Barr virus (EBV)es_ES
dc.subjectNuclear localization signal (NLS)es_ES
dc.subjectPhylogenyes_ES
dc.subjectRecombinationes_ES
dc.titleGenetic patterns found in the nuclear localization signals (Nlss) associated with ebv-1 and ebv-2 provide new insights into their contribution to different cell-type specificitieses_ES
dc.typeArticlees_ES


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