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dc.contributor.authorUdovin, Lucas Daniel
dc.contributor.authorOtero-Losada, Matilde
dc.contributor.authorBordet, Sofia
dc.contributor.authorChevalier, Guenson
dc.contributor.authorQuarracino, Cecilia
dc.contributor.authorCapani, Francisco
dc.contributor.authorPerez-Lloret, Santiago
dc.date.accessioned2021-04-22T03:50:38Z
dc.date.available2021-04-22T03:50:38Z
dc.date.issued2021-05
dc.identifier10.1016/j.parkreldis.2021.03.007
dc.identifier.issn13538020
dc.identifier.urihttps://hdl.handle.net/20.500.12728/8800
dc.description.abstractIntroduction: We explored the potential clinical effects of angiotensin-II AT1 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) in patients from the Parkinson's Progress Marker Initiative (PPMI) study database. Methods: We included 423 newly diagnosed PD patients, free from antiparkinsonian treatment, from the PPMI. We compared the proportion of patients starting on L-DOPA during the first year of follow-up, and the changes in MDS-UPDRS total score and sub-scores during the first five follow-up years for patients exposed or not to ARBs or ACEIs. Results: Treatment with ARBs did not affect the proportion of patients on L-DOPA during the first year (adjusted OR, 95% CI = 0.26, 0.03–2.18, N.S.) while reduced MDS-UPDRS total score (0.85, 0.76–0.95, p < 0.01). Patients treated with ACEIs experienced no changes in either measure. Conclusions: These results show potential signals for a beneficial effect with ARBs. Further clinical trials are warranted.es_ES
dc.language.isoenes_ES
dc.publisherElsevier Ltdes_ES
dc.subjectAngiotensin IIes_ES
dc.subjectAngiotensin receptor antagonistses_ES
dc.subjectAngiotensin-converting enzyme inhibitorses_ES
dc.subjectDisease modificationes_ES
dc.subjectNeuroprotectiones_ES
dc.subjectParkinson's diseasees_ES
dc.titleEffects of angiotensin type 1 receptor antagonists on Parkinson's disease progression: An exploratory study in the PPMI databasees_ES
dc.typeArticlees_ES


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