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dc.contributor.authorSousa, Alexandre C.C.
dc.contributor.authorRomo, Adolfo I.B.
dc.contributor.authorAlmeida, Raimundo R.
dc.contributor.authorSilva, Aiêrta C.C.
dc.contributor.authorUchoa Dutra Fechine, Lillian Maria
dc.contributor.authorAlmeida Brito, Débora Hellen
dc.contributor.authorMelo Freire, Rafael
dc.contributor.authorPascoalino Pinheiro, Daniel
dc.contributor.authorRibeiro Da Silva, Larissa Morais
dc.contributor.authorLoiola Pessoa, Otília Deusdênia
dc.contributor.authorCasagrande Denardin, Juliano
dc.contributor.authorPessoa, Claudia Do Ó.
dc.contributor.authorSilva Ricardo, Nagila Maria Pontes
dc.date.accessioned2021-04-22T03:23:43Z
dc.date.available2021-04-22T03:23:43Z
dc.date.issued2021-07-15
dc.identifier10.1016/j.carbpol.2021.118017
dc.identifier.issn01448617
dc.identifier.urihttps://hdl.handle.net/20.500.12728/8798
dc.description.abstractMagnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.es_ES
dc.language.isoenes_ES
dc.publisherElsevier Ltdes_ES
dc.subjectDrug delivery vehicleses_ES
dc.subjectMagnetic nanocarrierses_ES
dc.subjectNanocapsuleses_ES
dc.subjectOncocalyxone Aes_ES
dc.subjectProlonged releasees_ES
dc.subjectSPIONses_ES
dc.titleStarch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategyes_ES
dc.typeArticlees_ES


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