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dc.contributor.authorAndrade Neto, Davino M.
dc.contributor.authorda Costa, Luelc S.
dc.contributor.authorde Menezes, Fernando L.
dc.contributor.authorFechine, Lillian Maria Uchoa Dutra
dc.contributor.authorMelo Freire, Rafael
dc.contributor.authorCasagrande Denardin, Juliano
dc.contributor.authorBañobre-López, Manuel
dc.contributor.authorVasconcelos, Igor F.
dc.contributor.authorRibeiro, Thiago Soares
dc.contributor.authorLeal, Luzia Kalyne A.M.
dc.contributor.authorCosta de Sousa, João Antonio
dc.contributor.authorGallo, Juan
dc.contributor.authorAlmeida Fechine, Pierre Basílio
dc.date.accessioned2021-01-12T18:18:10Z
dc.date.available2021-01-12T18:18:10Z
dc.date.issued2021-03-30
dc.identifier10.1016/j.apsusc.2020.148824
dc.identifier.issn01694332
dc.identifier.urihttps://hdl.handle.net/20.500.12728/8131
dc.description.abstractThe great performance of functionalized Fe3O4 nanoparticles (NPs) as contrast agent for magnetic resonance imaging (MRI) is related to the functionalizing agents, once can tune colloidal properties, chemical stability, hydrophilicity, overall toxicity, as well as, dipole interparticle interactions. Phosphonate derivatives have proven to be excellent capping agents due to their ability to control the above parameters. However, the available functionalizing agents do not provide enough both attached and free-form phosphoric acid groups on NPs surface. Herein, we report the use of a commercially available amino-phosphonate compound, diethylenetriaminepenta (methylene phosphonic acid, DTPMP), to functionalize Fe3O4 NPs to be potentially applied as MRI contrast agent. For the synthesis of DTPMP-coated Fe3O4 NPs, two methodologies were applied, hydrothermal and sonochemical approaches. Several characterization techniques were performed, confirming the success of surface functionalization, which allowed a deep chemical discussion involving the interactions between DTPMP and Fe3O4 NPs. Furthermore, relaxivity and cytotoxicity analyses confirmed the MRI contrast agent potential of the DTPMP-coated Fe3O4 NPs, presenting non-cytotoxicity profile and high values of transverse relaxivity (357–417 mM−1 s−1). Therefore, this work presents a novel and excellent alternative magnetic material for biological and technological application, mainly considering MRI contrast agent.es_ES
dc.language.isoenes_ES
dc.publisherElsevier B.V.es_ES
dc.subjectAmino-phosphonatees_ES
dc.subjectFunctionalized magnetic nanoparticleses_ES
dc.subjectMRI contrast agentes_ES
dc.subjectSonochemistryes_ES
dc.titleA novel amino phosphonate-coated magnetic nanoparticle as MRI contrast agentes_ES
dc.typeArticlees_ES


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