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dc.contributor.authorDíaz-Peña, Roberto
dc.contributor.authorSilva, Rafael S.
dc.contributor.authorHosgood III, H. Dean
dc.contributor.authorJaime, Sergio
dc.contributor.authorMiravitlles, Marc
dc.contributor.authorOlloquequi, Jordi
dc.date.accessioned2020-09-28T20:59:53Z
dc.date.available2020-09-28T20:59:53Z
dc.date.issued2020-09-15
dc.identifier10.1016/j.arbres.2020.07.022
dc.identifier.issn03002896
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6921
dc.description.abstractIntroduction: While the molecular mechanisms of COPD pathogenesis remain obscure, there is mounting evidence supporting a key role for autoimmunity. Although human leukocyte antigens (HLA) alleles have been repeatedly associated with autoimmune processes, the relation between HLA and COPD remains largely unexplored, especially in Latin American (LA) populations. Consequently, this study aimed to investigate the presence of HLA class I and II alleles in COPD patients and healthy controls in a LA population with admixed ancestry. Methods: COPD patients (n = 214) and age-matched controls (n = 193) were genotyped using the Illumina Infinium Global Screening Array. The classic HLA alleles were imputed using HLA Genotype Imputation with Attribute Bagging (HIBAG) and the Hispanic reference panel. Finally, the distribution of HLA-DRB1 alleles was reexamined in 510 randomly recruited unrelated volunteers. Results: CODP patients showed a higher HLA-DRB1*01:02 allele frequency (6.54%) than healthy controls (3.27%, p = 0.04, OR = 2.07). HLA-DRB1*01:02 was also significantly associated with FEV1 (p = 0.04) and oxygen saturation (p = 0.02), and the FEV1/FVC ratio was higher in HLA-DRB1*15:01-positive patients (p = 9 × 10−3). Conclusion: We report an association among HLA-DRB1 alleles, COPD risk and pulmonary function parameters for the first time in Latin Americans. Since HLA-DRB1 genetic variability relates to the individual autoimmune response, these results support a role of autoimmunity in the pathogenesis of COPD.es_ES
dc.language.isoeses_ES
dc.language.isoEn
dc.publisherElsevier Doymaes_ES
dc.subjectAdmixturees_ES
dc.subjectAutoimmunityes_ES
dc.subjectGeneticses_ES
dc.subjectHLAes_ES
dc.subjectSNPes_ES
dc.titleHLA-DRB1 Alleles are Associated With COPD in a Latin American Admixed Populationes_ES
dc.title.alternativeLos alelos de HLA-DRB1 se asocian con la EPOC en una población latinoamericana mestizaes_ES
dc.typeArticlees_ES


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