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    Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms

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    Date
    2018
    DOI
    10.1007/s12035-017-0669-1

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    Author
    de Lemos L.
    Junyent F.
    Camins A.
    Castro-Torres R.D.
    Folch J.
    Olloquequi J.
    Beas-Zarate C.
    Verdaguer E.
    Auladell C.
    Abstract
    The activation of c-Jun-N-terminal kinases (JNK) pathway has been largely associated with the pathogenesis and the neuronal death that occur in neurodegenerative diseases. Altogether, this justifies why JNKs have become a focus of screens for new therapeutic strategies. The aim of the present study was to identify the role of the different JNK isoforms (JNK1, JNK2, and JNK3) in apoptosis and inflammation after induction of brain damage. To address this aim, we induced excitotoxicity in wild-type and JNK knockout mice (jnk1−/−, jnk2−/−, and jnk3−/−) via an intraperitoneal injection of kainic acid, an agonist of glutamic-kainate-receptors, that induce status epilepticus. Each group of animals was divided into two treatments: a single intraperitoneal dose of saline solution, used as a control, and a single intraperitoneal dose (30 mg/kg) of kainic acid. Our results reported a significant decrease in neuronal degeneration in the hippocampus of jnk1−/− and jnk3−/− mice after kainic acid treatment, together with reduced or unaltered expression of several apoptotic genes compared to WT treated mice. In addition, both jnk1−/− and jnk3−/− mice exhibited a reduction in glial reactivity, as shown by the lower expression of inflammatory genes and a reduction of JNK phosphorylation. In addition, in jnk3−/−mice, the c-Jun phosphorylation was also diminished. Collectively, these findings provide compelling evidence that the absence of JNK1 or JNK3 isoforms confers neuroprotection against neuronal damage induced by KA and evidence, for the first time, the implication of JNK1 in excitotoxicity. Accordingly, JNK1 and/or JNK3 are promising targets for the prevention of cell death and inflammation during epileptogenesis. © 2017, Springer Science+Business Media, LLC.
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    LA UNIVERSIDAD
    • Aseguramiento de Calidad
    • Internacional
    • Vinculación con el Medio
    • Más Transparencia
    • Acreditación
    • Reglamentos e instructivos
    • Reclamos y Sugerencias
    FACULTADES
    • Administración y Negocios
    • Arquitectura y Construcción
    • Ciencias de la Salud
    • Ciencias Sociales y Humanidades
    • Derecho
    • Educación
    • Ingeniería
    INVESTIGACIÓN
    • Estructura
    • Comités de Ética
    • Institutos de Investigación
    • Centros de Investigación
    • Grupos de Investigación
    • Docentes Investigadores
    POSTGRADOS
    • Postgrados
    • Doctorados
    • Magíster
    • Especialidades
    • Escuela Internacional
    • Escuela Alta Dirección