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dc.contributor.authorYaribeygi H.
dc.contributor.authorZare V.
dc.contributor.authorButler A.E.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:30:36Z
dc.date.available2020-09-02T22:30:36Z
dc.date.issued2019
dc.identifier10.1002/jcp.27843
dc.identifier.citation234, 6, 8610-8617
dc.identifier.issn00219541
dc.identifier.urihttps://hdl.handle.net/20.500.12728/6645
dc.descriptionThe prevalence of diabetes mellitus is growing rapidly worldwide. This metabolic disorder affects many physiological pathways and is a key underlying cause of a multitude of debilitating complications. There is, therefore, a critical need for effective diabetes management. Although many synthetic therapeutic glucose-lowering agents have been developed to control glucose homeostasis, they may have unfavorable side effects or limited efficacy. Herbal-based hypoglycemic agents present an adjunct treatment option to mitigate insulin resistance, improve glycemic control and reduce the required dose of standard antidiabetic medications. Saffron (Crocus sativus L.), whilst widely used as a food additive, is a natural product with insulin-sensitizing and hypoglycemic effects. Saffron contains several bioactive β carotenes, which exert their pharmacological effects in various tissues without any obvious side effects. In this study, we discuss how saffron and its major components exert their hypoglycemic effects by induction of insulin sensitivity, improving insulin signaling and preventing β-cell failure, all mechanisms combining to achieve better glycemic control. © 2018 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.subjectcrocin
dc.subjectCrocus sativus
dc.subjectdiabetes mellitus
dc.subjectinflammation
dc.subjectinsulin signal transduction
dc.subjectoxidative stress
dc.subjectsaffron
dc.subjectsafranal
dc.subjectantidiabetic agent
dc.subjectglucose transporter 4
dc.subjectherbaceous agent
dc.subjectnutraceutical
dc.subjectantidiabetic agent
dc.subjectbiological marker
dc.subjectinsulin
dc.subjectplant extract
dc.subjectantidiabetic activity
dc.subjectcell membrane
dc.subjectchemical composition
dc.subjectclinical trial (topic)
dc.subjectCrocus sativus
dc.subjectdrug effect
dc.subjectglucose transport
dc.subjectglycemic control
dc.subjecthuman
dc.subjectinflammation
dc.subjectinsulin sensitivity
dc.subjectinsulin signaling
dc.subjectnonhuman
dc.subjectoxidative stress
dc.subjectpancreas islet beta cell
dc.subjectpancreas islet cell function
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectprotein localization
dc.subjectReview
dc.subjectanimal
dc.subjectblood
dc.subjectchemistry
dc.subjectCrocus
dc.subjectdiabetes mellitus
dc.subjectdrug effect
dc.subjectglucose blood level
dc.subjectinsulin resistance
dc.subjectisolation and purification
dc.subjectmetabolism
dc.subjectpathophysiology
dc.subjectAnimals
dc.subjectBiomarkers
dc.subjectBlood Glucose
dc.subjectCrocus
dc.subjectDiabetes Mellitus
dc.subjectHumans
dc.subjectHypoglycemic Agents
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectInsulin-Secreting Cells
dc.subjectPlant Extracts
dc.titleAntidiabetic potential of saffron and its active constituents
dc.typeReview


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